In this large cohort of antibody-mediated AE, the UT-Hopkins Score demonstrated high sensitivity across most antibody subtypes, supporting its use to detect autoimmune causes early in patients presenting with encephalitis.
The results suggest that the NEOS score could be a useful prognostic tool for identifying poor outcomes in children with antibody-negative AE, but may lack discriminatory value in anti-NMDAR cases.
Son Thai Pham, Tam Tran, Mohammed Abdellatif et al.· European journal of paediatr...· 0 citations
All AE cases diagnosed in the study were anti-NMDAR (N-Methyl-D-aspartic acid receptor) positive encephalitis, suggesting undiscovered antigens should be considered in all microbiologically negative AES cases.
Jai Bhagwan, Urvashi Suman, Vikas Manchanda et al.· Indian Journal of Medical Mi...· 0 citations
AIM
To develop the Pediatric Autoimmune encephalitis Severity Scale (PASS) using expert consensus and the Delphi process, and validate it in children with autoimmune encephalitis.
METHOD
This prospective observational study enrolled children who underwent serial rating with PASS, the Clinical Assessment Scale in Auto...
Priyanka Madaan, Suvasini Sharma, A. Easton et al.· Developmental Medicine & Chi...· 1 citation
Intrathecal KFLC synthesis represents a highly sensitive CSF marker that supports early suspicion of autoimmune encephalitis and prompts antibody testing and NfL provides robust biochemical information on baseline disease severity and longitudinal changes that may aid prognostic assessment across AE subtypes.
F. Konen, E. Bucak, F. Bachhuber et al.· Neurology(R) neuroimmunology...· 0 citations
Long-term cognitive impairment and fatigue were prevalent in AE, despite good functional outcomes as measured by the mRS, and the MoCA correlated well with neuropsychological performance and could be the bedside test of choice if a neuropsychologist is not readily available.
T. Gaist, Lisbeth Rosenlund Lodahl, Henrik Akre Thorup et al.· Neurology(R) neuroimmunology...· 0 citations
Combined detection of neural autoantibodies, systemic autoimmune antibodies, and infection-related serological markers facilitates etiological diagnosis and identification of candidates for early immunotherapy in patients with unexplained seizures in western China.
Yushan Yuan, Yang Su, Min-Jin Wang et al.· BMC Immunology· 0 citations
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