ADSC-Exo-bFGF promotes skin wound healing and correlates with the PI3K/AKT signaling pathway activation

TGα2β-modified adipose-derived stem cell exosomes regulate collagen synthesis in fibroblasts and enhance chronic ulcerative wound repair through the ILK/AKT signaling pathway.

BACKGROUND Chronic ulcerative wounds, particularly diabetic foot ulcers, present a significant clinical challenge owing to their complex pathophysiology and limited response to conventional therapies. Although exosomes derived from adipose-derived mesenchymal stem cells (ADSC-exos) have shown promise in promoting tissu...

GJA1-mediated mitochondrial transfer from adipose-derived stem cells underpins the enhanced therapeutic efficacy of tetramethylpyrazine on wound healing

CCBE1 promotes wound healing in diabetic rats by improving the functional impairment of AD-MSCs induced by AGEs.

OBJECTIVE The etiology of chronic and non-healing diabetic wounds is manifold; the progression of the non-healing phenotype is strongly associated with poor vascular networks. Mesenchymal stem cells (MSCs) are reckoned as a promising therapy for wound healing, especially in angiogenesis. Here, we explored the role of C...

PDLIM2 Promotes Osteogenesis of Adipose-Derived Stem Cells by Modulating β-Actin-Dependent Wnt/β-Catenin Signaling.

BACKGROUND Bone tissue possesses strong regenerative potential, but large segmental bone defects often exceed its intrinsic capacity for self-healing. Human adipose-derived stem cells (hASCs) offer a promising cellular basis for bone regeneration owing to their robust osteogenic differentiation potential. However, the...

Synergistic Wound Healing Enhancement by Extracellular Vesicles From Engineered Macrophages and Fibroblasts.

Severe wound healing impairment risks persistent tissue damage and even necrosis. Cell-free exosome therapy demonstrates significant potential in wound healing due to its high efficacy and micro-volume characteristics. However, its clinical-scale translation faces challenges including low yield, limited sources, functi...

Bi-layered living cellular constructs promote recruitment and activation of an M2 macrophage phenotype

Skin substitutes, also known as Cellular and/or Tissue-based Products (CTPs), and wound dressings often are designed to support the innate wound healing response of the patient. The mechanism of action for these products varies, with some products strictly acting as bacterial barriers while others can alter the w...