Skip to content

Immunoregulatory Activity of Chinese Yam Polysaccharides on Cyclophosphamide-Induced Immunosuppression Mice via Regulating Gut Microbiota and Metabolic Pathway

Aug 2026 · Journal of Polymers and the Environment · Vol 34 · 0 citations · 60 references

TL;DR

It is suggested that CYPs potentially improve the immune-related indicators in CTX-induced immunosuppressed mice, accompanied by changes in immune organ integrity, gut microbiota composition, and host metabolic pathways.

View source

Similar papers

Sep 2026

Mannatide modulates immune response and gut microbiota in cyclophosphamide-induced immunosuppressed BALB/c mice.

It is highlighted that Mannatide is associated with immune recovery in CTX-treated mice, accompanied by changes in gut microbiota, SCFA production, and immune-related signalling pathways, and provide insights for adjuvant therapies targeting the gut-immune axis.

Yan-Jiao Feng, Yue Zeng, Xue Zhang et al. · 0 citations
Open access Sep 2026

Immunomodulatory effects of Sanghuangporus sanghuang polysaccharide SSP1 in cyclophosphamide-induced immunosuppressed mice: associations with gut microbiota, short-chain fatty acids, and metabolic remodeling

Immunosuppression induced by chemotherapeutic agents such as cyclophosphamide (CTX) is frequently associated with gut microbiota dysbiosis. Sanghuangporus sanghuang polysaccharide (SSP1) possesses immunomodulatory potential; however, its effects on mucosal immunity and the gut microbiota remain unclear....

Kun Liu, Xin-Yao Fu, Yi-Hang Liu et al. · 0 citations
Open access Sep 2026

HAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism

Introduction Dietary supplementation with functional starches serves as a promising intervention strategy for immune regulation, yet the immunomodulatory efficacy and underlying mechanisms of newly developed modified starch derivatives remain to be further explored. In this study, a cyclophosphamide (CTX) induced secon...

Di Zhang, Ying-Ying Song, Shi-Hao Guo et al. · 0 citations
Open access Sep 2026

Modulatory Effect of the Alfalfa Polysaccharide Fraction II on Cyclophosphamide-Induced Immunosuppression in Mice.

This study investigated the protective effects of alfalfa polysaccharide fraction II (APS-II) on immunosuppression induced by cyclophosphamide (CTX) in mice. APS-II was extracted using ultrasound-assisted enzymatic extraction method and purified by DEAE-52 cellulose chromatography. Its structural characteristics, inclu...

Feng-Wei Li, Zhi-Yun Yan, Na Mu et al. · 0 citations
Sep 2026

Tetramethylpyrazine ameliorates metabolic dysfunction-associated steatohepatitis by modulating gut microbiota dysbiosis and restoring intestinal barrier integrity.

BACKGROUND AND PURPOSE This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH). EXPERIMENTAL APPROACH Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...

Xiao-Li He, Linzhang Zhang, Ya-Di Zhu et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.