Immunoregulatory Activity of Chinese Yam Polysaccharides on Cyclophosphamide-Induced Immunosuppression Mice via Regulating Gut Microbiota and Metabolic Pathway
Aug 2026· Journal of Polymers and the Environment· Vol 34· 0 citations· 60 references
TL;DR
It is suggested that CYPs potentially improve the immune-related indicators in CTX-induced immunosuppressed mice, accompanied by changes in immune organ integrity, gut microbiota composition, and host metabolic pathways.
It is highlighted that Mannatide is associated with immune recovery in CTX-treated mice, accompanied by changes in gut microbiota, SCFA production, and immune-related signalling pathways, and provide insights for adjuvant therapies targeting the gut-immune axis.
Yan-Jiao Feng, Yue Zeng, Xue Zhang et al.· International Journal of Bio...· 0 citations
Immunosuppression induced by chemotherapeutic agents such as cyclophosphamide (CTX) is frequently associated with gut microbiota dysbiosis.
Sanghuangporus sanghuang
polysaccharide (SSP1) possesses immunomodulatory potential; however, its effects on mucosal immunity and the gut microbiota remain unclear....
Kun Liu, Xin-Yao Fu, Yi-Hang Liu et al.· Frontiers in Immunology· 0 citations
Introduction Dietary supplementation with functional starches serves as a promising intervention strategy for immune regulation, yet the immunomodulatory efficacy and underlying mechanisms of newly developed modified starch derivatives remain to be further explored. In this study, a cyclophosphamide (CTX) induced secon...
Di Zhang, Ying-Ying Song, Shi-Hao Guo et al.· Frontiers in Immunology· 0 citations
This study investigated the protective effects of alfalfa polysaccharide fraction II (APS-II) on immunosuppression induced by cyclophosphamide (CTX) in mice. APS-II was extracted using ultrasound-assisted enzymatic extraction method and purified by DEAE-52 cellulose chromatography. Its structural characteristics, inclu...
Feng-Wei Li, Zhi-Yun Yan, Na Mu et al.· Journal of Food Science· 0 citations
Findings support the dual potential of AMLF in functional foods and as immunomodulatory adjuvant in functional foods and as immunomodulatory adjuvants.
BACKGROUND AND PURPOSE
This study investigated the therapeutic effects and gut-liver axis-related mechanisms of tetramethylpyrazine (TMP) in metabolic dysfunction-associated steatohepatitis (MASH).
EXPERIMENTAL APPROACH
Male C57BL/6 mice were fed a methionine- and choline-deficient (MCD) diet for 6 weeks to establish...
Xiao-Li He, Linzhang Zhang, Ya-Di Zhu et al.· British Journal of Pharmacol...· 0 citations
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