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Jul 2026

Relationship between BDNF rs6265 (VAL66MET) polymorphism and serum BDNF LEVELS in anxiety disorders

It is demonstrated that decreased serum BDNF levels are associated with the presence and symptom severity of anxiety disorders, and the Val66Met polymorphism does not appear to be a primary determinant of serum BDNF levels in this population, suggesting that other genetic or environmental factors may be involved.

Dicle Yilmaz Uyanik, Merve Şahin Can, O. Baykan et al. · 0 citations
Jul 2026

Association of BDNF Val66Met polymorphism with clinical severity, cognitive function, and treatment response in schizophrenia

BDNF Val66Met polymorphism was significantly associated with clinical symptom severity, cognitive function, and treatment-related improvement among Acehnese individuals with schizophrenia, and the Val/Val genotype was associated with a more favorable clinical and cognitive profile and stronger early clinical and cognitive response.

Juwita Saragih, Irwan Saputra, Marty Mawarpury et al. · 0 citations
Open access Jul 2026

Serotonin transporter polymorphism (5-HTTLPR) is associated with post-awakening cortisol measures in previous depression

It is suggested that 5-HTTLPR-related differences, when present, may be more detectable in overall post-awakening cortisol output than in baseline-relative increase, which is more detectable in overall post-awakening cortisol output than in baseline-relative increase.

R. Jonassen, Ø. .. Ø. verli, E. Hilland et al. · 0 citations
Open access Aug 2026

Associations between high perceived stress, inflammatory proteins, and BDNF: a cross-sectional study of young adult females in Shanghai, China.

Psychological stress accelerates aging, increasing morbidity and mortality risks, though the mechanisms behind this relationship are still under investigation. This cross-sectional study explored the link between perceived stress and blood protein profiles by recruiting healthy female subjects (aged 18-35) stratified into high (HS) and low (LS) perceived stress groups according to self-reported subjective questionnaires in Shanghai, China. The HS group displayed a higher tendency of neuroticism along with depression, anxiety, and emotional volatility. The exploratory proteomic analysis of blood samples was performed, evaluating 92 inflammation/immune related proteins using the Olink high-throughput platform. Concurrently, targeted analysis of pre-specified stress-related neurological biomarkers including brain-derived neurotrophic factor (BDNF) and oxytocin were performed using Enzyme-linked immunosorbent assay (ELISA). The results demonstrated that the HS group displayed elevated levels of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1, log2FC = 0.565) and sirtuin 2 (SIRT2, log2FC = 0.383). Age-segregated analysis (early young adult (EYA), 18-25 years old; middle young adult (MYA), 25-30 years old; late young adult (LYA), 30-35 years old) revealed that BDNF was decreased in the LYA group and demonstrated a moderate negative correlation with 4E-BP1 and SIRT2. Cytokines interleukin-8 (IL-8) and IL-10 were also significantly elevated in the LYA group. These findings indicated that Chinese, young women with HS exhibit distinct inflammatory profiles and reduced BDNF levels, suggesting that chronic stress may be associated with increased inflammation and compromised neuronal plasticity, highlighting the need for future longitudinal studies to clarify the long-term impact of stress on mental wellbeing.

Ping Gao, Hong Zhang, Xue Xiao et al. · 0 citations
Open access Aug 2026

Is Stress Reactivity an Intermediary Mechanism in the Association Between NR3C1 Methylation and Adolescent Loneliness?

This study examined whether saliva-derived DNA methylation in the glucocorticoid receptor (NR3C1) gene was linked to loneliness through dysregulation of the hypothalamic-pituitary-adrenal axis (HPA-axis) in 101 early adolescents (Mage = 11.61 years, SDage = 0.64, 55.45% girls). Using person-centered analyses to account for interindividual differences in adolescents' stress reactivity, we identified three subgroups of cortisol responders to a social evaluative stressor: A hyporesponsive subgroup (30.5%), a moderate-responsive subgroup (44.2%), and a hyperresponsive subgroup (25.3%). Exploratory analyses also identified subgroups for two markers of the autonomous nervous system (ANS), that is, heart rate (HR) and skin conductance (SC). Furthermore, the indirect effects from NR3C1 methylation to early adolescent loneliness via individual differences in stress responses were examined. Results indicated that higher NR3C1 methylation levels were associated with a lower probability of belonging to the most reactive stress response subgroups for cortisol and HR, and to the high mean-level subgroup for SC. Additionally, higher probabilities of belonging to the low mean-level SC subgroup were associated with higher levels of loneliness. However, there was no evidence that NR3C1 methylation was associated with early adolescent loneliness, either directly or indirectly via stress reactivity. These findings highlight significant individual differences in stress reactivity, emphasizing the need to explicitly consider such variability in future research. Moreover, the results suggest that NR3C1 methylation is linked to individual differences in stress responding, warranting further investigation.

Yentl Koopmans, S. Nelemans, Patricia Bijttebier et al. · 0 citations
Open access Aug 2026

Anxiety and Depression Traits Are Moderated by a Sex-Dependent Genetic Interaction Between 5-HTTLPR and BDNF

The findings reveal a complex, sex-dependent genetic interaction that selectively influences anhedonia and anxiety, which highlights the value of considering sex-stratified genetic backgrounds and symptom specificity to advance personalised precision medicine in psychiatry.

G. L. Odierna, C. Sharpley, V. Bitsika · 0 citations