The utility of PVC-derived nanosyringes is expanded and DAAT is established as a modular platform for intracellular antimicrobial peptide therapy for treatment of Staphylococcus aureus infections.
Findings identify cyclotide grafting as a strategy to improve peptide stability and intracellular delivery, and support MCo-KTR2 as a scaffold for further optimization against intracellular MRSA infections.
Álvaro Mourenza, Jesús Llano-Verdeja, Pablo Castañera et al.· Molecular Biomedicine· 0 citations
These findings establish EVs as effective vehicles for intracellular delivery of antimicrobial enzymes and highlight their potential for the treatment of intracellular bacterial infections.
B. Sabani, M. Leone, Lynn Gasser et al.· Materials Today Bio· 0 citations
Findings position resveratrol-antibacterial peptide mimic conjugates as a promising antimicrobial candidate for combating MRSA-associated wound infections and provide valuable insights for the development of novel antimicrobial agents.
Huixiao Fu, Jun-Hang Zhang, Wen-Qiang Huang et al.· European journal of medicina...· 0 citations
Antimicrobial peptides (AMPs) are evolutionarily conserved molecules that play a central role in innate immunity and represent a promising class of candidates against antimicrobial resistance. However, their clinical application is hindered by low stability in physiological conditions, susceptibility to proteolytic deg...
Bruno Amorim-Carmo, Emanuell Santos-Silva, Alessandra Daniele-Silva et al.· Biomedicine & pharmacotherap...· 0 citations
A single-atom nanozyme is reported by coupling ferriporphyrin containing monocarboxyphenyl (mFeP) and cell wall binding domain of endolysin from Staphylococcus aureus phage via a bioorthogonal reaction to achieve targeted catalytic elimination of methicillin-resistant Staphylococcus aureus (MRSA).
Bin Hong, Jie Wang, Bing Hu et al.· Small· 0 citations
It is confirmed that enhanced host immune activation and direct antibacterial activity result in a significant reduction of intracellular S. aureus in primary murine osteoblasts, highlighting the therapeutic potential of this platform.
Leyla Danai, Christina J. Bayard, Krishna Majithia et al.· ACS nano medicine· 0 citations
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