Overall, this study provides a systems-level computational investigation of Pleurotus ostreatus-derived compounds and their potential interactions with cancer-associated targets, however, these findings are based on computational predictions and require further experimental validation to confirm their biological and therapeutic relevance.
This study investigated Altissimacoumarin H (ATSC), a naturally occurring terpenylated coumarin, using an integrated in silico workflow combining target prediction, network pharmacology, transcriptomic assessment, molecular docking, molecular dynamics, ADME/toxicity prediction, and density functional theory (DFT).
S. Bufarwa, M. Belaidi· Journal of Computational Bio...· 0 citations
Findings support the hypothesis that ICA may serve as a valuable natural compound for treating HER2‐driven breast cancer; it requires further experimental validation.
The results suggest that A. cardamomum could serve as a potential source for developing new plant-based therapies against breast cancer and further in vitro and in vivo investigations are warranted to validate their efficacy and safety.
Dessy Arisanty, S. Khairani, K. Cuandra et al.· F1000Research· 0 citations
Abstract Objective This study assessed the pharmacological prospects of Pteridaceae phytoconstituents using an integrated network pharmacology (NP) and computational molecular docking (MD) strategy. Materials and Methods Various peer-reviewed literature databases, including ScienceDirect, PubMed, Scopus, and Google Sch...
P. Gupta, Pankaj Sharma, A. K. Yadav et al.· Ibnosina Journal of Medicine...· 0 citations
An integrative, network pharmacology approach was employed to elucidate the multi-target mechanism of action of phytochemicals derived from Glossocardia bosvallia against NSCLC, providing a robust strategy for identifying biologically relevant and therapeutically actionable targets supporting the potential of G. bosval...
S. Kulandhaivel, A. Stalin, Pandiyan Muthuramalingam et al.· Computational biology and ch...· 0 citations
The study provides a scientific basis for the development of novel plant-derived therapeutic agents and highlights the importance of network pharmacology and molecular docking approaches in modern drug discovery research against pancreatic cancer.
Vaishnavi Kurade, Ajit Lad, Nilaji Lad et al.· International Journal of Res...· 0 citations
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