Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10‐day bed rest in older adults

This work aimed to characterise how physical inactivity impacts mitochondrial function, morphology and gene expression in the skeletal muscle of older adults.

Exercise metabolism: MoTrPAC-ing the liver in endurance exercise.

The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a comprehensive research program designed to elucidate the molecular pathways induced by exercise. As a continuation of MoTrPAC studies, Kelty et al. report dynamic and sex-dimorphic molecular responses in rats through which endurance exercise regul...

Functional and Structural Adaptations of Skeletal Muscle to Functional and Structural Adaptations of Skeletal Muscle to Microgravity Microgravity

Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice

The 5xFAD brain retains modest molecular responsiveness to prolonged voluntary exercise but may be unable to mount a sufficiently robust or coordinated response to produce broad neuroprotective effects, highlighting disease context as an important determinant of the efficacy of exercise-based interventions in neurodege...

Protein restriction and the hallmarks of aging: A coordinated physiological adaptive response?

This work proposes that protein restriction extends lifespan across species and engages many hallmarks of aging as components of a single coordinated physiological state, with enhanced longevity emerging from this adaptive response.

Elevation of body temperature during exercise enhances protection against dexamethasone‑induced skeletal muscle atrophy

It is indicated that exercise‐induced elevation of body temperature enhances protection against glucocorticoid‐induced skeletal muscle atrophy and support a role for heat‐associated cellular stress responses in modulating muscle protein turnover during glucocorticoid exposure.