2026· ITEGAM- Journal of Engineering and Technology for Industrial Applications (ITEGAM-JETIA)· Vol 12, pp. 49-56· 0 citations
TL;DR
Simulations closely matched experiments, confirming that Zn and PLGA strengthen natural HAp and make the composite a promising, cost-effective choice for orthopaedic implants.
Abstract
Bone-derived hydroxyapatite (HAp) is highly biocompatible but lacks mechanical strength. This study addresses this limitation by adding zinc (Zn) and poly (lactic-co-glycolic acid) (PLGA) to enhance performance. We synthesised goat-bone HAp via calcination and chemical treatment, incorporated Zn to improve crystallinity and antibacterial activity, and reinforced it with PLGA for better flexibility and load-bearing capacity. Finite element modelling in ANSYS (100–1000 N loading) showed that pure HAp is stiff but brittle, Zn-HAp is stronger, and the PLGA-Zn-HAp composite has the greatest toughness, stress distribution, and fracture resistance. Simulations closely matched experiments, confirming that Zn and PLGA strengthen natural HAp and make the composite a promising, cost-effective choice for orthopaedic implants.
Sr-doped HAp nanorods demonstrate tunable mechanical and functional properties, highlighting their potential as multifunctional materials for bone-related applications requiring both structural performance and localized therapeutic action.
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One of the most studied biomaterials for biomedical applications is hydroxyapatite (HAp), a bioactive ceramic (Ca-P) with structural and compositional similarity to the mineral phase of human bones and teeth. HAp is investigated for various applications, such as bone regeneration, dental implants, tissue engineering, i...
