Analysis of the previously reported antibacterial beddomeilactone amide (3g) as a potential DNA gyrase inhibitor of S. aureus underscores potent hit (3g) as a promising candidate for the development of an antibacterial agent against S. aureus by targeting DNA gyrase.
Findings identify resveratrol as a promising anti-virulence candidate and highlight the utility of integrative computational and experimental strategies for the identification of compounds targeting quorum sensing and biofilm formation inhibition in multidrug-resistant pathogens.
Mashego Jackson Mamosebo, Suheena Ayrga, S. Madhi et al.· Archives of Microbiology· 0 citations
This study presents a structure-based screening workflow that identified potential inhibitory hits supported by in vitro antibacterial evaluation that may reduce the likelihood of resistance emergence by simultaneously disrupting multiple essential bacterial pathways.
Luv Singhal, Neeraj Kumar, C. Sharma et al.· Discover Chemistry· 0 citations
The data suggest para-methoxy substitution improves antibacterial activity, meriting further studies on solubility enhancement, metabolic stability and in vivo validation.
Ankit Goel, K. Yadav, Tanya Jain et al.· Oriental Journal of Chemistr...· 0 citations
This review comprehensively summarizes the design, synthesis, biological evaluation, and structure-activity relationships of heterocyclic GyrB inhibitors, highlighting the therapeutic potential of quinoline, thiazole, pyrrole, benzimidazole, benzofuran, azaindole, benzothiazole, pyrazole, pyridine, and related scaffold...
Raju Ninave, V. Kumar, Vandana et al.· RSC Medicinal Chemistry· 0 citations
Mechanistic study showed that 24a effectively inhibits biofilm formation and exerts its antibacterial effect by disrupting the bacterial cell membrane, paving the way for new strategies to combat antimicrobial resistance.
Qiong Wu, Bing-Yuan Yan, Chen Qu et al.· Chinese Journal of Natural M...· 0 citations
