Aug 2026· Molecular Psychiatry· 0 citations· 133 references
Medicine
TL;DR
This synthesis synthesizes multimodal evidence from human neuroimaging, post-mortem tissue analysis, clinical cohorts, and preclinical animal studies to delineate the distinct regulatory logics governing peripheral and cerebral iron metabolism, and constructs a unified mechanistic framework illustrating how diverse etiological factors drive region- and cell-specific iron perturbations and subsequent circuit dysfunction.
Neuroinflammatory mechanisms are increasingly recognized in biologically defined subgroups of psychiatric disorders, yet the cellular interfaces linking peripheral immune activation to brain dysfunction remain incompletely understood. This review examines the blood-brain barrier (BBB) and neurovascular unit (NVU) as dy...
Larli Misael Pérez-López, Alberto Camacho-Morales, I. Howland-Álvarez et al.· Frontiers in Molecular Neuro...· 0 citations
Major depressive disorder (MDD) is a heterogeneous psychiatric disorder involving oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired neuroplasticity, and metabolic dysregulation. Ferroptosis, an iron-dependent form of regulated cell death driven by phospholipid peroxidation and antioxidant defense...
De-Yue Kong, Rui-Qi Duan, Xiang-Yu Wang et al.· Biochemistry and Biophysics...· 0 citations
Converging findings point to brain- and body-wide energetic dysregulation in psychotic disorders, implicating metabolic abnormalities across different levels of investigation, including genetic, cellular, postmortem, and in vivo neuroimaging studies. The present review synthesizes this literature documenting aberrant e...
Jacey Anderson, Kai-Christian Sonntag, Thao Do Vy Le et al.· The FEBS Journal· 0 citations
Emerging therapeutic strategies targeting microglia were discussed, including anti-inflammatory approaches, functional reprogramming, neuromodulation techniques, and microglial replacement or niche engineering, indicating a paradigm shift from indiscriminate microglia inhibition to the precise modulation of specific fu...
J. R. de Jesus, I. S. Ribeiro, Marcos V. S. Pereira et al.· Advances in Immunology· 0 citations
Neurodegenerative diseases are a heterogeneous group of chronic and progressive disorders, which are characterized by selective neuronal destruction, synaptic malfunction and progressive cognitive and locomotor dysfunction. The major ones are Alzheimer disease, Parkinson disease, Huntington disease, and amyotrophic lat...
Nisha, Sumairah Qadir· Current Pharmaceutical Resea...· 0 citations
Major depressive disorder (MDD) is a prevalent and disabling psychiatric disorder characterized by persistent mood disturbances, cognitive impairments, and significant systemic consequences. Despite its substantial clinical burden, diagnosis remains challenging because current approaches rely largely on subjective symp...
D. Iskakova, Burcu Yener, A. Kamzanova et al.· Frontiers in Integrative Neu...· 0 citations
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