Transcriptomic profiling and structural characterization reveal UQCRC1 and COX4I1 as key mitochondrial regulators associated with oxidative stress in multiple sclerosis.

TL;DR

It is demonstrated that mitochondrial respiratory chain-related pathways, particularly those involving complexes III and IV, are consistently associated with the transcriptomic alterations observed in multiple sclerosis, providing evidence that mitochondrial bioenergetics and redox homeostasis may contribute to MS pathobiology.