Past achievements and future perspectives of personalized vaccines and the role of dendritic cells

Therapeutic cancer vaccines: development, challenges, and future perspectives.

The promising cancer treatment approach in cancer immunotherapy: dendritic cell-based vaccines

Dendritic cells (DCs), as the most protent professional antigen-presenting cells (APCs), possess an exceptional capacity to initiate and modulate adaptive immune responses, rendering DC-based vaccines a highly promising approach in tumor immunotherapy. This review explores the biological properties of DCs, establishing...

Therapeutic melanoma vaccines: Platforms, neoantigen strategies, and emerging combination immunotherapies

Melanoma has emerged as a major focus of cancer immunotherapy research because of its highly immunogenic nature and responsiveness to immune-based treatments. Therapeutic melanoma vaccines are designed to stimulate tumor-specific immune responses through the delivery of Tumor-Associated Antigens (TAAs), Tumor-Specific...

Take Five: harmonization in personalized cancer vaccines for cancer immunotherapy

It is proposed that the future maturation of PCVs will require a coordinated process across five interconnected dimensions: advances in neoantigen prediction technologies, rapid delivery of PCVs to patients, an increase in anticancer efficacy through combination therapy strategies, establishment of cost-effective manuf...

Cancer vaccines as targeted therapies: translational advances and challenges.

Cancer vaccines represent a promising class of immunotherapeutic agents with potential applications in cancer prevention and treatment. By eliciting tumor-specific immune responses, these vaccines may offer durable protection against tumor progression, recurrence, and metastasis while minimizing off-target toxicity ass...

Therapeutic Cancer Vaccines: Classification, Mechanisms, Challenges and Future Perspectives.

BACKGROUND With the rapid advancements in oncology, immunology, and molecular biology, immunotherapy has emerged as a cornerstone of anti-tumor treatment, complementing traditional modalities such as surgery, radiotherapy, and chemotherapy. Therapeutic cancer vaccines are a promising immunotherapy strategy that deliver...