Formononetin Attenuates Seizure Severity and Cognitive Deficits in PTZ-Kindled Rats with Associated Changes in Oxidative Stress and P2 X 7/IL-1β/Glutamate Signalling Markers

Open access Jul 2026

Impact of Imipenem on Cognitive Function, Anxiety-like Behaviour, Neurogenesis, and Astrogliosis in Pentylenetetrazol-Kindled Rats

It is suggested that imipenem modulates the cellular substrate of the pre-sensitized brain, interfering with hippocampal plasticity and glial compensatory mechanisms, rather than directly driving further behavioural deterioration.

Leonardo Araújo-Andrade, Pedro Nogueira, Bárbara Caetano-Mota et al. · Antibiotics · 0 citations

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Open access Sep 2026

Lamotrigine Attenuates Lipopolysaccharide-Induced Working-Memory Impairment and Is Associated with Changes in Neuroinflammatory, Oxidative-Stress, and Apoptosis-Related Markers

Highlights What are the main findings? Lamotrigine (LTG) ameliorated lipopolysaccharide (LPS)-induced working-memory impairment and suppressed neuroinflammatory responses in the prefrontal cortex. LTG reduced oxidative stress and pro-apoptotic signaling while restoring endogenous antioxidant and anti-apoptotic defenses...

Bashair Hamed Alharbi, A. A. A. Alshammari, V. Mani · Brain Science · 0 citations

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Jul 2026

Trigonelline attenuates valproic acid-induced autism-like behaviours in rats: histopathological changes of the hippocampus, modulation of gene expressions related to neuroinflammation and blood-brain barrier permeability.

Investigation of Trigonelline's effects on autistic phenotype, gene expression of tight junction proteins associated with BBB integrity, neuroinflammation and histopathological changes in the hippocampus in valproic acid - induced autism in rats found it significantly attenuated autistic behaviors.

Zahra Forouzandeh Shahraki, A. Noori, Hossin Amini-Khoei et al. · World Journal of Biological... · 0 citations

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Open access Aug 2026

Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations

Findings demonstrate associations between carvedilol treatment and multiple pathological processes during PTZ-induced kindling, but do not establish direct pathway-specific causality.

Ahmed H. Madkour, Rania R. Abdelaziz, Manar A. Nader et al. · Scientific Reports · 0 citations

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Open access Aug 2026

Dose-dependent effects of fingolimod on behavioral, molecular, and Stereological outcomes in a rat model of intracerebroventricular streptozotocin-induced Alzheimer’s disease-like cognitive dysfunction

Fingolimod exerted dose-dependent, domain-specific effects, with lower doses improving functional outcomes and the intermediate dose providing greater preservation of hippocampal structure, suggesting beneficial effects within the doses examined.

Alireza Khani-Robati, Mohammad Banizaman, Farima Jahromi et al. · 3 Biotech · 0 citations

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Open access Sep 2026

Resveratrol’s Neuroprotective Effects on the Retina in a Pentylenetetrazol-Induced Epilepsy Model in Rats: Insights into SIRT1 Signaling, Apoptosis, and Gliosis

Background/Objectives: A chronic neurological disorder known as epilepsy results in neurodegeneration, oxidative stress, and damage to the retina and the central nervous system’s structure. The main objective of this research was to examine the neuroprotective benefits of Resveratrol (RES) on the retina in a model usin...

O. Unal, N. Akgun-Unal, Elif Gulbahce-Mutlu et al. · Antioxidants · 0 citations

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