Efficacy and safety of oliceridine versus sufentanil in perioperative anesthesia and analgesia: a systematic review and meta-analysis with trial sequential analysis
Aug 2026· European Journal of Clinical Pharmacology· Vol 82· 0 citations· 45 references
Medicine
TL;DR
Preliminary findings indicate that oliceridine reduces the risks of respiratory depression and PONV compared with sufentanil, while analgesic efficacy and hemodynamic stability were comparable in Chinese adults.
Background To compare the efficacy and incidence of adverse reactions of oliceridine versus sufentanil in patient-controlled intravenous analgesia (PCIA) for postoperative pain management following gynecological laparoscopic surgery. Methods In this randomized, double-blind trial, 152 patients undergoing elective gynec...
Jing-Mei Zhou, Zhuangbo Wu, Yuqing Lai et al.· Frontiers in Medicine· 0 citations
OBJECTIVE
Tegileridine, a novel G protein-biassed μ-opioid receptor agonist, may offer effective postoperative analgesia with fewer opioid-related adverse effects. This study evaluated its analgesic efficacy, safety and impact on surgical stress response vs. sufentanil for patient-controlled intravenous analgesia (PCIA...
Ying-Chuan Yuan, Zi-Lin Pan, Yun-Chao Zhou et al.· British Journal of Clinical...· 0 citations
BACKGROUND
Remimazolam is a novel ultra-short-acting intravenous benzodiazepine, while sevoflurane is a widely used inhalational anaesthetic for general anaesthesia (GA). Both agents are associated with risks of haemodynamic instability and postoperative nausea and vomiting (PONV), which can affect patient safety and r...
L. Takayama, Kevlin de Souza, David Abraham Batista da Hora et al.· European Journal of Anaesthe...· 0 citations
Objectives To evaluate the analgesic efficacy and safety of intraoperative intravenous methadone compared with conventional opioid-based analgesic regimens in adult patients undergoing cardiac surgery, using data derived from randomized controlled trials and retrospective cohort studies. Methods A comprehensive retriev...
Wei Li, Yuandi Ye, Jian-Qiong Zhou et al.· Frontiers in Medicine· 0 citations
Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) for data from 1990 until July 2024 to id...
K. Pirie, A. Yap, M. Lopez-Olivo et al.· Current Anesthesiology Repor...· 0 citations
Abstract Background Perioperative administration of esketamine has been reported to improve early quality of recovery (QoR). However, data on its effects in outpatient surgery are limited. This study aimed to assess the impact of esketamine on QoR in patients undergoing outpatient gynecological procedures. Methods In t...
Xu-Lin Wang, Yan-Na Li, Qiao-Ling Ma et al.· Annals medicus· 0 citations
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