TL;DR
PP is highlighted as an environmental risk factor for gallstones, providing novel insights into their prevention and targeted therapy, and its role in gallstone pathogenesis remains unclear.
Background Bisphenol A (BPA) is a pervasive environmental contaminant associated with various systemic toxicities. However, its specific mechanistic involvement in dry eye disease (DED) pathogenesis is not defined. This study aimed to evaluate the toxicological mechanisms of BPA in DED pathogenesis and identify the key...
Abstract Purpose Exogenous chemical exposure is closely associated with allergic rhinitis (AR). Methyl 4-hydroxybenzoate (MeP), a widely used preservative, poses risks of long-term human exposure. This study aimed to explore the potential association between MeP and AR as well as its underlying molecular characteristic...
Findings provide mechanistic evidence linking DEHP exposure to kidney stone pathogenesis by disrupting apoptosis–autophagy homeostasis in renal tubular epithelial cells.
Analysis of plasma from α-amanitin-poisoned mice preliminarily reveals that plasma metabolites follow a temporally dynamic progression across seven different groups, which is consistent with the toxicological injury–response–adaptation model.
The pathophysiology of acute pancreatitis (AP), a common clinical emergency, is poorly understood. Previous studies have implicated N6-methyladenosine (m6A) modification in the pathogenesis of AP; however, the precise molecular mechanisms remain unclear. Whether metabolites participate in this process is also an import...
6PPD-quinone (6PPD-Q), a transformation product of the tire antioxidant 6PPD, is an emerging traffic-related contaminant with well-documented ecotoxicity in aquatic species. Its recent detection in airborne particulate matter, road dust, and human urine has raised concerns about possible human health effects. However,...
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