Aug 2026· Natural Product Research· pp.
1-11
· 0 citations· 31 references
Medicine
TL;DR
This is the first report on GMPS inhibition by phenolic compounds, and the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS.
Abstract
Plant bacterial diseases threaten global food security and agricultural product quality. This study aimed to explore natural products with anti-phytopathogenic bacterial activity towards the new target guanosine monophosphate synthase (GMPS). Twelve phenolic compounds, including a new one, peniquinone L (1), were isolated using column chromatography and semipreparative HPLC from Chaetomium grande-JPT2. The molecular structures of the isolated compounds were determined by HRESIMS, 1D and 2D NMR spectrometry. High-throughput activity screening revealed that compound 11 could inhibit GMPS, yielding an EC50 value of 58.83 μg/mL. Molecular docking further revealed that the binding interaction between 11 and GMPS was primarily stabilised by two hydrogen bonds formed between the hydroxyl group in 11 and amino acid residues in GMPS. This is the first report on GMPS inhibition by phenolic compounds. Furthermore, compounds 4 and 7 displayed antibacterial activity against Xanthomonas axonopodis by two-fold serial dilution method, with MIC values of 100 μg/mL.
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BACKGROUND
The persistent proliferation of bacterial phytopathogens presents a significant threat to global food security and agricultural sustainability. Among these pathogens, species belonging to the genus Xanthomonas are particularly destructive. Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial le...
Yu-Guo Zheng, Mei-Hang Chen, Hua Sun et al.· Pest Management Science· 0 citations
Aquaculture and environmental challenges continue to constrain the industry’s sustainable development. The misuse of antimicrobial agents has accelerated the dissemination of resistance genes, posing a serious threat to both animal husbandry and human health. Thus, the discovery of novel antibiotic alternatives is of g...
You-Ying Chen, Geng-Tao Chen, Cheng-Yang Hsieh et al.· International Journal of Mol...· 0 citations
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