Jul 2026· Journal of Biochemistry (Tokyo)· 0 citations
Medicine
TL;DR
Investigation of the formation and quantitative significance of Nω-(carboxyethyl)arginine (CEA), an underexplored MGO-derived arginine adduct indicates that CEA is a reliable marker for evaluating MGO-mediated protein degeneration and dicarbonyl stress in vitro and in vivo.
These findings highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation, and highlight plumbagin as a potent multifunctional compound capable of mitigating MGO-induced glycation.
Faiza Iram, Ayesha Aiman, Deepanshi Vijh et al.· Journal of Cellular Biochemi...· 0 citations
Increased metabolic stress associated with diabetes and cancer increases the level of reactive dicarbonyl molecules that covalently modify nucleic acids. Methylglyoxal (MG), one of the most abundant endogenous dicarbonyl electrophiles, reacts with guanine bases in DNA and RNA to form covalent adducts that compromise...
Alana Battad, Francisco Núñez, S. Lai et al.· Chemical Research in Toxicol...· 0 citations
Methylglyoxal (MGO), a highly reactive 1,2-dicarbonyl, is generated by all three principal pathways of advanced glycation end product (AGE) synthesis in type 2 diabetes mellitus (T2DM)—the Hodge, Namiki, and Wolff pathways—and by the non-enzymatic degradation of glycolytic triose phosphates. It is the principal substra...
It is demonstrated that NAC effectively attenuates d‐ribose‐induced glycation and protein aggregation in vitro and provides mechanistic insights into its anti‐glycation properties through multiple complementary biochemical mechanisms.
Rabia Nabi, Tabrez Faruqui, M. S. Khan et al.· IUBMB Life - A Journal of th...· 0 citations
Background/Objectives: Methylglyoxal-derived hydroimidazolone-1 (MG-H1), an advanced glycation end product, has implications in the pathogenesis of diabetic kidney disease (DKD). Although liquid chromatography–mass spectrometry is the current gold standard for quantifying MG-H1, its overall complexity limits its utilit...
Jun Nojima, Masatsuna Tasaka, H. Fujigaki et al.· Diagnostics· 0 citations
Protein posttranslational modifications (PTMs) play a central role for regulating protein function and cellular processes, with many PTMs arising from reactions with electrophilic metabolites. Here we extend the known landscape of PTMs with the identification of "lysine C3-iminylation," the conjugation of protein lysin...
Bing-Sen Zhang, Yu-Heng Hsieh, Tyler R. Bales et al.· Proceedings of the National...· 0 citations
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