Methotrexate as an adjunct to pars plana vitrectomy for the prevention and treatment of proliferative vitreoretinopathy in rhegmatogenous retinal detachment: A clinical study.
Aug 2026· Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie· 0 citations· 17 references
Medicine
TL;DR
Adjunctive intravitreal methotrexate markedly improves morphological and functional outcomes in PVR-associated RRD, resulting in higher single-surgery success rates, reduced need for reoperation, and fewer postoperative sequelae.
PURPOSE
This study aimed to evaluate the impact of intraoperative mitomycin-C (MMC) application during pars plana vitrectomy (PPV) on anatomical success, the need for additional surgery, and visual outcomes in patients with recurrent rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopath...
Emre Avcı, E. Özal, S. Ermiş et al.· Retina· 0 citations
Endolaser retinopexy was associated with significantly higher anatomical success than cryotherapy, with combined treatment yielding intermediate outcomes in PPV for inferior RRD, and no significant association was observed between anatomical outcome and tamponade choice or PFCL use.
Purpose: The purpose of this study is to evaluate anatomical, visual, and safety outcomes after repeat pars plana vitrectomy combined with 360° encircling scleral buckling for first recurrent rhegmatogenous retinal detachment following primary vitrectomy. Methods: This retrospective single-centre cohort included 47 eye...
G. Panos, Alex Stubbing-Moore, D. Kumudhan et al.· Journal of Clinical Medicine· 0 citations
Vitrectomy combined with perifoveal centrifugal massage was associated with favorable anatomical and functional recovery in stage 4 EIFL-ERM, and this adjunctive technique may facilitate earlier stage regression and represents a potential refinement to standard iERM surgery.
L. Karabas, E. O. Tokuc, G. Kilic et al.· Retinal cases & brief report...· 0 citations
Purpose: To evaluate the incidence, predictors, and clinical impact of treatment-emergent epiretinal membrane (ERM) in diabetic macular edema (DME) treated with dexamethasone implant, aflibercept, ranibizumab, bevacizumab, or faricimab. Methods: In this multicenter, retrospective, nonrandomized study, 501 eyes with cen...
Debdulal Chakraborty, T. Sinha, R. Biswas et al.· Pharmaceuticals· 0 citations
PURPOSE
To determine whether adjunctive 0.025% povidone-iodine irrigation during pars plana vitrectomy might improve ocular morbidity in infectious endophthalmitis compared to standard irrigation.
METHODS
Multicenter, retrospective, comparative cohort study (2019-2024) at four tertiary referral centers. 63 eyes from...
Melissa Yuan, Keerti Pally, Brian K. Do et al.· Retina· 0 citations
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