Flype: Integrating Molecular and Pharmacogenomic Results to Enhance Oncology Patient Care in a Community-Based Academic Cancer Center

Evolution of Precision Oncology, Personalized Medicine, and Molecular Tumor Boards.

Evidence is accumulating to support feasibility and survival benefit in patients treated with matched therapy, and the incorporation of molecular targeted therapies and immunotherapy into the perioperative setting requires clinicians to understand the role of the MTB.

Effectiveness of a Molecular Tumor Board in Making Personalized Treatment Recommendations for Patients with Advanced Cancer

Translational Insights From the Molecular Landscape to Precision Therapy in Peripheral T-Cell Lymphoma: Integrating Multi-Omics and Artificial Intelligence.

This review synthesizes current molecular insights, evaluates the limitations of existing therapies, and explores the potential of multi-omics profiling integrated with artificial intelligence (AI) to decode complex signatures for improved subtype classification, treatment response prediction, and survival prognosticat...

Molecular therapy matching score correlates with clinical outcomes: a system for navigating cancer complexity

An algorithmic Matching Score is described that evaluates cancer drugs’/drug combinations’ ability to address a patients’ entire next-generation sequencing/multi-omic-derived molecular profile and underscores the clinical importance of the precision medicine approach that maximizes matching of multiple molecular altera...

Hyperpersonalization of cancer care: From tumor location to molecular profile - Key insights and the role of Hospital Oncology Pharmacists. A French Society for Oncology Pharmacy paper.

For decades, cancer treatment was largely organ-based, relying on conventional modalities such as surgery. Advances in molecular biology and biotechnology have profoundly transformed this paradigm by revealing shared oncogenic mechanisms across diverse tumor types. This shift has enabled the emergence of precision onco...

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable gen...