Nanogel for Cancer Drug Delivery: A Review of Recent Advances and Therapeutic
TL;DR
The present review provides a comprehensive overview of nanogels, their types, and effects on various types of cancers.
Abstract
Cancer is one of the leading causes of death around the globe. The conventional cancer therapies have several drawbacks, like non-specific biodistribution, poor stability, and significant systemic toxicity. Nanogels are increasingly recognized as a promising type of nanocarrier for cancer therapy because of their structural versatility, biocompatibility, and remarkable drug-loading efficiency. As cross-linked polymeric hydrogel nanoparticles, they offer multiple benefits, including enhancing the solubility of hydrophobic drugs, enabling controlled and stimulus-responsive release, improving tumour-specific delivery through the enhanced permeability and retention (EPR) effect, and reducing systemic toxicity. Recent progress in nanogel engineering has introduced smart modifications such as pH-, temperature-, enzyme-, and redox-responsive designs, which allow exact and localized drug release within the tumor microenvironment. The present review provides a comprehensive overview of nanogels, their types, and effects on various types of cancers.