TL;DR
It is suggested that ginsenoside Rh1 may mitigate allergic reactions through a multi-target and multi-pathway network, providing a theoretical basis for its development as a promising anti-allergic agent.
CNZP exhibits significant therapeutic effects on RA, potentially by downregulating NOS1 expression and subsequently correcting the metabolic imbalance of L-arginine, and this preclinical study provides mechanistic evidence for the anti-RA effect of CNZP.
BACKGROUND Rosacea is a chronic inflammatory skin disorder with limited therapeutic options. Puhuaiyin (PHY), a traditional Chinese medicinal formula, shows clinical efficacy, but its multi-component mechanisms remain unclear. METHODS Chemical constituents of PHY were identified by UPLC-Q-TOF-MS. Network pharmacology...
Sepsis is a life-threatening condition caused by a dysregulated host immune response to infection, often leading to organ failure. Increasing antibiotic resistance, particularly in Streptococcus pneumoniae, highlights the urgent need for alternative therapeutic strategies. Nigella sativa, known for its anti-inflammator...
Findings provide mechanistic insights into the multi-target pharmacological potential of C. sinensis phytochemicals and highlight their prospective therapeutic relevance against cancer, metabolic, inflammatory, and neurodegenerative disorders.
It is suggested that Isatis indigotica acts on HBV-associated hepatic inflammation through multi-target synergistic regulation of NF-κB and JAK-STAT signaling pathways, providing mechanistic insights and potential therapeutic targets for HBV management.
Results indicate that GQYS treats DN mainly through the anti-inflammatory effects, providing a potential theoretical basis for its clinical application and demonstrating the reliability of the integrative strategy.
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