TL;DR
Results suggested that compound 23 was a viable lead candidate for the treatment of Hp infection, and could cause severe cellular damage, disrupt biofilms, and inhibit urease, thereby blocking ammonia cloud formation.
The β-clamp protein is identified as a therapeutic target and CID 546,407 as a promising lead for drug development, driven by robust Van der Waals forces, which avoids the massive entropic penalties hindering other compounds.
Invasive candidiasis, particularly caused by drug-resistant strains, has emerged as a significant contributor to morbidity and mortality among hospitalized patients worldwide, posing a serious public health challenge. With the rising resistance to conventional antifungal agents such as azoles and echinocandins, the sea...
Compound F4 emerges as a promising lead for antifungal drug development, distinguished by its broad‑spectrum activity, antibiofilm properties, and unique capacity to eliminate FLC tolerance.
Mechanistic study showed that 24a effectively inhibits biofilm formation and exerts its antibacterial effect by disrupting the bacterial cell membrane, paving the way for new strategies to combat antimicrobial resistance.
The development of innovative treatment medicines that can overcome drug resistance and intracellular persistence is necessary since tuberculosis (TB) continues to be a significant worldwide health burden. In this work, series of hybrid compounds containing azole moieties, imine/semicarbazide linkers, and isonicotinoyl...
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