Through the analysis of this successfully treated case, clinical insights are derived and potential limitations are identified, with the goal of exploring effective diagnostic and therapeutic approaches for pediatric patients with non-tuberculous mycobacterial (NTM) infections in the future.
Abstract
The diagnosis and treatment of Mycobacterium abscessus infections present significant challenges, especially in the rare cases of extrapulmonary involvement in pediatric patients. These cases are characterized by diagnostic difficulties, limited therapeutic options, scarce clinical experience, and a lack of evidence-based treatment guidelines. This article reports on a 6-year-old child who experienced fever and abdominal pain. Metagenomic next-generation sequencing (mNGS) facilitated the rapid and accurate identification of Mycobacterium abscessus as the causative pathogen. Under a standardized full-course protocol, an individualized therapy regimen (that includes Imipenem, Azithromycin, and Linezolid) led to favorable clinical outcomes. Through the analysis of this successfully treated case, we aim to derive clinical insights and identify potential limitations, with the goal of exploring effective diagnostic and therapeutic approaches for pediatric patients with non-tuberculous mycobacterial (NTM) infections in the future.
P pulmonary Emergomyces orientalis infection is uncommon and prone to missed diagnosis and misdiagnosis with high mortality, so individualized antifungal treatment, strict drug interaction assessment and therapeutic monitoring are essential to optimize clinical prognosis.
The case of a 48-year-old patient recently diagnosed with HIV and a CD4 lymphocyte count of less than 50 cells/ uL, who consulted for prolonged fever without apparent focus, highlights the importance of considering nocardiosis in the differential diagnosis of prolonged fever with multiple deep lesions in immunocompromi...
María Trinidad Pennini Guelfi, Camilo Martínez, Ana De Lajonquiere et al.· Medicina· 0 citations
Abstract Isolated tuberculous abscess of the liver is an extremely rare clinical entity and represents a diagnostic challenge, as it can easily be confused with other hepatic lesions of infectious or tumoral origin. We report the case of a 67-year-old immunocompromised female patient with no known history of tuberculos...
Imane Bentaher, F. Bssaibis, Y. Ben Lahlou et al.· Access Microbiology· 0 citations
Non-tuberculous mycobacterial (NTM) infections are increasingly recognised as a cause of pulmonary and extrapulmonary disease, particularly in tuberculosis-endemic settings. We report seven cases of NTM infection diagnosed using clinical assessment, radiological findings, microbiological testing, and Line Probe Assay....
Bhavya Sharda, Falguni Agarwal, Shaina Gaikwad et al.· Indian Journal of Medical Mi...· 0 citations
Streptococcus intermedius is a gram-positive commensal associated with suppurative infections. Pediatric pulmonary abscesses due to S. intermedius are rare, and outcomes in children with severe neurological comorbidities are poorly characterized. A 5-year-old boy with refractory epilepsy and global developmental delay...
Shu-Teng Ou, Shu-Hua Chen, Ting Wang et al.· Frontiers in Medicine· 0 citations
Background: Cutaneous tuberculosis (CTB) is a rare extrapulmonary manifestation of tuberculosis, particularly in neonates. Its diagnosis is often challenging due to non-specific presentations that can mimic common conditions. Clinical Description: We report the case of a 22-day-old male neonate who presented to the eme...
Arisha Imran, Syeda Wareesha Fareeduddin Shah, Syed Abdul Rafayuddin Shah et al.· Current Health Sciences Jour...· 0 citations
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