A systematic review of physiological Ca2+ handling mediated by plasma membrane channels, transporters, and intracellular organelles in the cerebral vasculature emphasizes Ca2+ signaling as a promising therapeutic target to break the vicious cycle of neurovascular impairment and neurodegeneration in AD.
Brain endothelial cells (BECs) are specialized components of the neurovascular unit that couple circulating signals to cerebral blood flow regulation, blood–brain barrier (BBB) function, and selective molecular transport. This narrative review evaluates the correlation of these endothelial functions with psychiatric...
Meng-Jie Zhang, Xue-Ying Huang, Lin Yao et al.· Frontiers in Cellular Neuros...· 0 citations
Neurodegenerative diseases are increasingly linked to systemic metabolic dysfunction, with brain insulin resistance (BIR) positioned as a central mediator. Yet translating this insight into effective therapies has proven remarkably difficult. This review argues that BIR-driven neurodegeneration should be interpreted at...
Man Xiang, Si-Yu Cao, Xue-Heng Sun et al.· Translational Neurodegenerat...· 0 citations
Cerebral small vessel disease (CSVD) is a heterogeneous group of disorders involving the cerebral microvasculature and is a major cause of stroke and vascular cognitive impairment. The role of blood–brain barrier (BBB) dysfunction in CSVD is now recognized as a key pathological process; however, conventional vascular r...
Mei Xie, Shuang Wu, Ling Yang et al.· Frontiers in Neurology· 0 citations
An inflammation-centered model is proposed in which BBB breakdown and peripheral immune dysregulation form a pathogenic loop that accelerates neurodegeneration, and targeting this BBB–peripheral immune axis may provide new opportunities for biomarker development, patient stratification, and combination therapy beyond c...
Zu-Li Yang, Zhi-Qiang Xiao, Bin Huang et al.· Frontiers in Immunology· 0 citations
Alzheimer's Disease (AD) is a complex disorder whose underlying biology is not fully explained by traditional single-pathway models. For several decades, research has largely focused on the roles of amyloid-β and tau in the formation and deposition of plaques and neurofibrillary tangles associated with AD pathology and...
Desh Deepak Singh· Current Neuropharmacology· 0 citations
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