This narrative review synthesizes current mechanistic and clinical insights into cytokine dysregulation, explicitly distinguishing acute systemic cytokine release syndrome (CRS), often observed during CAR-T cell therapy, from chronic, tumor-localized cytokine amplification within the tumor microenvironment (TME).
ABSTRACT
Immune-mediated inflammatory diseases (IMIDs) refer to a heterogeneous group of conditions driven by dysregulated immune responses that affect multiple organs and systems, leading to substantial morbidity and premature mortality. Accumulating evidence indicates that excessive interleukin-6 (IL-6) production an...
Pengyu Ji, Peng-Fei Zhao, Wei Guo et al.· Chinese Medical Journal· 0 citations
Together, current evidence indicates that MDSCs represent context-dependent therapeutic nodes, while functional reprogramming, spatially resolved profiling, and patient stratification may improve immunotherapy outcomes.
Lisichen Zhu, Hui Liu, Sihan Zhang et al.· Cancer Letters· 1 citation
Immune checkpoint blockade targeting PD-1/PD-L1 has reshaped cancer therapy across multiple tumor types. However, primary and acquired resistance remain major barriers to durable clinical benefit. Increasing evidence indicates that immunotherapy resistance is not driven by isolated molecular alterations, but by coordin...
Chao Wang, Dong Yang· Frontiers in Cell and Develo...· 0 citations
Cytokine release syndrome (CRS) is a major limitation of current immunotherapy. Inflammatory complications are prone to occur after chimeric antigen receptor T-cell therapy and other immune-binding strategies. Cytokine overproduction is a well-defined feature of CRS. Yet the progression of CRS involves a complex interp...
Wen-Xin Xie, Xiao-Ling Su, Zhi-Jie Huang et al.· Cytokine & growth factor rev...· 0 citations
A
BSTRACT
Psoriasis is a chronic immune-mediated skin disorder, characterized by keratinocyte hyperproliferation and inflammatory cell infiltration. The interleukin-23 (IL-23)/IL-17 axis has been established as a central driver of disease pathogenesis, and biologics targeting this pathway has significantly improv...
The tumor microenvironment (TME) is a complex ecosystem that dynamically regulates tumor progression and therapeutic responses. Within this environment, innate immune cells play prominent dual roles, acting as both critical mediators of anti-tumor surveillance and facilitators of tumor immune escape. This review compre...
Song-Hang Xing, Jia-Yu Zhang, Shuang Wang et al.· Frontiers in Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
