TL;DR
Salidroside exerts protective effects in sepsis-associated ALI, which may be associated with modulation of the ERK/FoxO3a signaling axis, improvement of impaired autophagic flux, and maintenance of mitochondrial function.
BACKGROUND Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated. OBJECTIVES The aim of this st...
BACKGROUND Sepsis-Associated Acute Kidney Injury (SA-AKI) is a lifethreatening complication with high mortality and limited treatment options. Daphnetin (DAP), a coumarin derivative with anti-inflammatory activity, has shown promise in several inflammatory disorders, but its role in SA-AKI remains unclear. METHODS We...
The mechanism underlying the protective effects of Acacetin (AC) against sepsis-induced diaphragmatic dysfunction (SIDD) remains to be elucidated. AC is present in several medicinal plants and has many pharmacological effects and has been reported to inhibit ferroptosis. This study aimed to investigate the role of AC...
Hepatic ischemia-reperfusion injury (HIRI) remains a critical complication in liver surgery with limited pharmacological options, and while Farrerol (FA), a natural dihydroflavone, has shown protective effects in other organ IR models, its role in HIRI has never been explored. In this study, we established a murine mod...
BACKGROUND Sepsis-induced myocardial injury is a life-threatening complication. Isoquercitrin (IQC), a natural flavonoid glycoside, exhibits anti-inflammatory and anti-apoptotic properties, yet its role in septic cardiomyopathy remains unclear. METHODS IQC targets were predicted via transcriptomics and molecular dock...
Dysfunction of the vascular endothelial barrier is a pivotal event in the pathogenesis of sepsis-induced multiple organ dysfunction syndrome (MODS). Myricetin (MYR), a naturally occurring flavonoid compound with diverse biological activities, has not been previously reported for its role and mechanism in septic vascula...
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