Perfusion imaging-guided risk stratification and endovascular decision-making in low-NIHSS large-vessel occlusion stroke: a systematic review and exploratory meta-analysis
Aug 2026· Journal of Neurology· Vol 273· 0 citations· 38 references
Medicine
TL;DR
A systematic review and exploratory meta-analysis of studies evaluating perfusion or hemodynamic imaging in adults with low-NIHSS LVO stroke found large Tmax-defined hypoperfusion volumes, larger perfusion lesion volumes, and impaired hemodynamic reserve were associated with early neurological deterioration or poor functional outcome.
BACKGROUND AND PURPOSE
Despite high rates of macrovascular recanalization, approximately half of patients with large vessel occlusion stroke fail to achieve functional independence after endovascular thrombectomy (EVT). Residual tissue-level perfusion abnormalities - detectable on post-procedural CT perfusion (CTP) - h...
R. Eichel, Michael Teitcher, S. Mausbach et al.· Journal of Stroke & Cerebrov...· 0 citations
Background: Multiple trials have evaluated the benefits of endovascular thrombectomy (EVT) in patients with large-core ischemic stroke. This study aimed to determine the efficacy and safety of EVT compared with medical management (MM) alone in patients with large ischemic core infarcts. Methods: This study was register...
Abdullah M. Alkutbi, H. Almohammed, Ahmed Salah Morad et al.· The Neuroscientist· 0 citations
Objective Acute ischemic stroke (AIS) is a leading cause of death and disability. Timely reperfusion improves outcomes, but optimal patient selection depends on neuroimaging; CT is fast and widely available, whereas MRI offers greater precision in identifying salvageable brain tissue. This systematic review (SR) and me...
Sabia Afreen, Michelle Sámano Sánchez, Montserrat Villa Sánchez et al.· Frontiers in Neurology· 0 citations
Background Patients with minor ischemic stroke may still experience early neurological deterioration when severe intracranial stenosis or occlusion is present. The optimal role of endovascular treatment (EVT) in this imaging-defined population remains uncertain. This study aimed to evaluate clinical outcomes associated...
Xiang-Jie Gao, Liqiong Ren· Frontiers in Neuroscience· 0 citations
BACKGROUND
The role of balloon guide catheters (BGC) in endovascular thrombectomy for acute ischemic stroke remains controversial, with conflicting evidence regarding clinical outcomes. We evaluated the impact of BGC use on periprocedural metrics and early neurological improvement (ENI).
METHODS
In this retrospective...
Natalie van Landeghem, Katharina Kölker, Jordi Kühne Escolà et al.· Neuroradiology· 0 citations
NFS on post-treatment MRI is a robust imaging biomarker of persistent perfusion deficits and associated with decreased likelihood of successful long-term outcomes even after successful reperfusion.
Cynthia Greene, H. Salim, D. Lakhani et al.· Neuroradiology· 0 citations
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