Findings support nose-to-brain nano-delivery as a promising strategy for targeting inflammasome-driven neuroinflammatory pathology by mitigating aluminum-induced neurodegeneration by modulating the redox–NF-κB/NLRP3 inflammatory axis, leading to structural and functional recovery.
RA ameliorated cognitive dysfunction in BCAS mice by suppressing microglial oxidative stress and neuroinflammation and attenuating BBB-related disruption and the data suggest that RA provide a pharmacological strategy for BCAS-associated cognitive impairment.
6-OH-F ameliorates Aβ-induced cognitive impairment by attenuating oxidative stress, neuroinflammation, and pyroptotic signaling, potentially through modulation of the TLR4/NF-κB/NLRP3 pathway, highlighting its therapeutic potential in Alzheimer's disease.
A synergistic pathogenic cascade where α-synuclein accumulation contributes to neuroinflammation and oxidative stress, suppressing antioxidant defenses and activating apoptotic pathways is suggested, ultimately leading to dopaminergic neuron death and severe motor dysfunction.
Homa Vali Pour, M. Alfateh, Sanaz Mirzayan Shanjani et al.· Biochemical and Biophysical...· 0 citations
Cardiovascular diseases are increasingly linked to environmental toxicants, including widely used organophosphate pesticides. This study investigates the cardiotoxic potential of chlorpyrifos (CPF) and dimethoate (DM) using complementary in vivo and in vitro models. Female Wistar rats were orally exposed to CPF, DM and...
Jasmeena Jan, Salman Shamas, Wajid Mohammad Sheikh et al.· Journal of Applied Toxicolog...· 0 citations
Highlights What are the main findings? Manganese exposure is associated with hippocampal oxidative stress, mitochondrial dysfunction, neuroinflammation, neurotransmitter imbalance, and apoptosis, with structural neuronal damage in rats. Liposomal honokiol nanoparticles are associated with reversal of Mn-induced alterat...
Raed AlRuwaili, E. Elmorsy, M. Abdel-Daim et al.· Brain Science· 0 citations
Current evidence indicates that BBR modulates signaling pathways, reduces the production of pro-inflammatory cytokines, attenuates oxidative stress, and limits glial activation, and several studies suggest that BBR may help preserve the functional integrity of the blood–brain barrier and reduce neuronal damage associat...
María Del Refugio Moyetón-Hernández, C. Bandala, Mariana Guadarrama-Castillo et al.· Nutrients· 0 citations
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