Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 66 references
Medicine
TL;DR
CMF and SLM appear to exert complementary neuroprotective and remyelinating effects, CMF principally promoting oligodendrocyte-mediated remyelination and SLM limiting oxidative and inflammatory injury that together converge on the PI3K/Akt/mTOR axis, supporting simultaneous dual-target intervention as a rational strategy for MS.
Multiple sclerosis (MS) is an incurable and progressive inflammatory disease of the central nervous system (CNS) characterized by inflammatory demyelination, chronic axonal damage, and neurodegeneration. Carabrone (CA), a sesquiterpene lactone from the traditional Chinese herb Carpesium abrotanoides L., demonstrates di...
Huai-Ping Tang, Liang Sun, Bin Jia et al.· European Journal of Pharmaco...· 0 citations
NDF treatment markedly ameliorated clinical EAE severity, reduced spinal cord infiltration of T cells—particularly Th1 cells—and promoted myelin and axonal preservation, supporting its role as beneficial modulator in neuroinflammation.
David Freudenstein, Anna Schneeweiss, Adriana Krenz et al.· PLoS ONE· 1 citation
A review examines the GSNO/GSNOR axis as an emerging therapeutic target in MS, highlighting its mechanistic roles in selective immune modulation, the regulation of neuroinflammation, and the attenuation of oxidative stress.
Je-song Won, Judong Kim, A. Singh et al.· Frontiers in Immunology· 0 citations
This review explores apigenin, a natural compound abundantly found in parsley, chamomile, and citrus fruits, focusing on its anti-inflammatory and neuroprotective properties as a potential adjuvant treatment for multiple sclerosis.
Monique Reis de Santana, N. N. Silva, J. V. D. de Oliveira et al.· Biology· 0 citations
Multiple sclerosis (MS) has conventionally been considered a prototypical autoimmune disorder. While modern immunotherapies effectively control relapsing conditions, they fail to avert progressive neuroinflammation, neurodegeneration, and remyelination failure. This review offers an evidence-based recontextualization....
Ghada A. Badawi, Rehab M. El-Sayed, Mohamed N. Fawzy· InflammoPharmacology· 0 citations
Background Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease characterized by T lymphocyte infiltration and demyelination that can lead to severe disability without treatment. However, effective treatment for MS remains an unmet need. 2′-deoxyinosine (2′-DI), an endogenous nucleoside, has been impl...
Da-Qing Wang, Jia-Xuan Zhu, Zhuo Wang et al.· Frontiers in Pharmacology· 0 citations
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