New Approaches to Regulating Gonadal and Thyroid System Activity

The extragonadal biology of gonadotropin hormones: should we rename these?

Current understanding of direct actions of FSH and LH on bone, adipose tissue, and brain and focus specifically on the detrimental health burden during and after the menopause: osteoporosis, obesity, and dementia are reviewed.

Expressionn of the Thyroid Stimulating Hormone Receptorr in the Folliculo-Stellate Cells oF the Human Anteriorr Pituitary

Pubertal Triptorelin Exposure Alters Hypothalamic Reproductive–Metabolic Integration in a Sex-Specific Manner

GnRHa treatment induced the suppression of reproductive function in rats of both sexes, evidenced by changes in ovaries and testes and in pituitary markers important for the control of reproduction.

S14.1 - Tissue specific thyroid hormone signalling

The human thyroid gland primarily synthesizes thyroxine (T4), a metabolically stable prohormone requiring mostly extrathyroidal peripheral deiodination to T3 for cellular activity. The hypothalamic-pituitary-thyroid (HPT) axis maintains a relatively stable circulating thyroid hormone (TH) level. However, TH signaling...

TR11 Differential TSH receptor signaling induced by luteinizing hormone and human chorionic gonadotropin

Human chorionic gonadotropin (hCG) shares structural homology with thyroid-stimulating hormone (TSH) and contributes to thyroid hormone production during pregnancy through activation of the TSH receptor (TSHR). Although hCG and luteinizing hormone (LH) bind the same receptor (LHCGR), their effects on TSHR signali...

Gonadotropin-releasing hormone and the lungs

Gonadotropin-releasing hormone (GnRH) medications are used to treat a wide range of reproductive disorders. GnRH regulates not only the maturation and growth of the gonads, but also the immune system and metabolism, thereby affecting non-reproductive, somatic tissues. GnRH affects the lungs, but research findings are...