Single-cell roadmap of bovine oogenesis and somatic niche interactions during fetal ovarian development

C. Guiltinan R. Botigelli R. Arcanjo Justin M. Smith Courtney K. Grimm S. Plummer Brendan Keough Mark N. Paulsen Sandeep K. Rajput Benjamin P. Beaton A. Denicol

Aug 2026 · bioRxiv · 0 citations · 57 references

Biology

TL;DR

A single-cell RNA-sequencing atlas of the bovine fetal ovary at four gestational timepoints is presented, capturing the progression of PGCs through commitment, meiotic entry, and early oocyte growth and providing a developmental roadmap for bovine oogenesis at the single-cell resolution that advances fundamental understanding of gametogenesis and informs strategies for advanced assisted reproduction.

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