This review systematically examines the multifaceted barrier mechanisms affecting peptides digestion and absorption, elucidates their in vivo transport pathways, and proposes cutting-edge strategies to enhance bioavailability.
This review assesses the critical role of the food matrix (FM) in regulating peptide bioavailability, addressing the new challenge of overcoming low oral absorption of diverse peptide classes and advocating for matrix-engineered delivery systems (such as microencapsulation and probiotic fermentation) to establish a hol...
Chunhong Liu, Chao-Qing Wen, O. Olatunji et al.· The Journal of the Science o...· 2 citations
The findings suggest that measurable oral peptide absorption is unlikely to result from a single dominant pathway but rather from the cumulative contribution of the mechanisms, which may open opportunities to enhance oral peptide bioavailability and support the development of more effective therapeutics.
Lania Ali Hussein, Alexandra Nedic, Andrejs Šitovs et al.· Pharmaceutics· 0 citations
This comprehensive review summarizes current knowledge of flavonoids, including their classification into 14 main groups and their production via biosynthesis, chemical synthesis, modification, and extraction, and discusses potential drug interactions warranting clinical attention.
M. El-Saadony, A. Saad, Mohamed A. Fahmy et al.· Frontiers in Nutrition· 0 citations
This review summarizes the exploration of conjugated peptides by discussing their sequences, antioxidant activity, and conjugation methods to provide information that will support the discovery of additional antioxidant peptide conjugates for future research.
Zenita Fatimah, Rani Maharani, J. Al-Anshori et al.· Mini-Reviews in Organic Chem...· 0 citations
Abstract Flavonoids are a class of naturally occurring compounds primarily present in plants and are also part of some of the byproducts of certain insects’ metabolites, such as propolis. Given the growing burden of infectious diseases and the urgent need for more effective therapeutic options, advancing flavonoid-base...
Sayed M. Saleh, Riaz A. Khan, L. Aroua et al.· International Journal of Nan...· 0 citations
A critical integration of evidence brings together sources, structure–activity relationships, production, molecular mechanisms, pharmacokinetics, formulation technologies, clinical applications, safety and regulation information in the context of this narrative review of bioactive peptides and polyphenols.
T. Wani· Natural Resources for Human...· 1 citation· ⚡1
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