TL;DR
The anatomical connections of the NAc with the underexplored brainstem and cerebellar connections are investigated, demonstrating overlapping connections in both species, particularly with the raphe, parabrachial, ventral tegmental area and pontis oralis.
The nucleus accumbens (NAc) orchestrates a range of critical physiological functions, including reward and motivation, yet single-neuron-level connectivity of its inputs and outputs remains less comprehensively characterized. Here, we examined the organizing principle of input and projection of medium spiny neurons (MS...
The basal forebrain septum separates the lateral ventricles and comprises the septum pellucidum and septum verum, the latter containing the septal nuclei. These nuclei are involved in cognitive, emotional, and autonomic function and are implicated in psychiatric and neurological disorders, including Alzheimer’s disease...
This work uses cell type-specific retrograde anatomy and ex vivo slice physiology and optogenetics to characterize the properties of synapses onto CINs in the NAc core of mice of either sex, and establishes how these inputs and receptors evoke action potentials and influence spontaneous firing.
Cerebral cortex and cerebellum are intimately connected enabling them to perform their functions in learning, controlling and executing our daily movements. This review aims to provide a summary of both the cortico-cerebellar as well as of the cerebello-cortical routes that are used in their interaction. As such, this...
The precise neuromodulatory mechanisms underlying consciousness and its disorders, despite growing evidence in both animals and humans, remain poorly understood at the subcortical level. The basal ganglia, a key component of the cortico-basal ganglia-thalamo-cortical loop, are known to play a crucial role in mediating...
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