TL;DR
The findings elucidate the neuroanatomical basis of NIID’s core symptoms and highlight regional brain atrophy as a potential imaging biomarker for disease monitoring and future therapeutic trials.
Background and Objectives: X-linked dystonia-parkinsonism (XDP) is a severe neurodegenerative movement disorder caused by a retrotransposon insertion with a polymorphic hexanucleotide repeat expansion in the TAF1 gene. While the disease predominantly affects males, female carriers may exhibit a variable phenotypic expr...
Background and Objectives Anti–leucine-rich glioma–inactivated 1 encephalitis (LGI1E) is traditionally considered as limbic encephalitis, but emerging evidence characterizes LGI1E as a whole-brain disorder. Furthermore, most neuroimaging studies have relied on cross-sectional designs and purely volumetric measures. Her...
Parkinson's disease (PD) encompasses motor and neuropsychiatric symptoms (NPS) including depression, anxiety, and apathy. Cognitive subtypes—PD with mild cognitive impairment (PD‐MCI) and PD with dementia (PDD)—and the related Dementia with Lewy Bodies (DLB) exist within the spectrum of Lewy body disease (LBD). While N...
The study revealed structural brain abnormalities in aMCI, characterized by reduced hippocampal and hippocampal subfield volumes, as well as amygdala volume reduction, while other subcortical structures were relatively preserved.
PURPOSE Progressive supranuclear palsy (PSP) and Alzheimer's disease (AD) exhibit different tau distributions. We compared tract-specific associations between florzolotau(18F) retention, white matter (WM) microstructure, and clinical impairment. METHODS Forty-nine patients with PSP, 40 with AD, and 30 cognitively uni...
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