It is demonstrated that chronic stress disrupts central energy metabolism at prefrontal cortical synapses, driving to synaptic pathology and behavioral vulnerability and highlighting synaptic metabolic pathways as promising pharmacological targets for the treatment of stress-related psychiatric disorders.
H. Nagai, K. Ota, C. Numa et al.· International Journal of Neu...· 0 citations
This study provides the first evidence that hippocampal Tenm4 deficiency induces depression-like behavior phenotypes through impaired oligodendrocyte differentiation and promoting demyelination.
Yuichiro Sugimori, Y. Yano, Takashi Asano et al.· Neuropharmacology· 0 citations
Stress may elicit two regionally heterogeneous microglial subpopulations within NAC: phagocytosis-enhanced and recognition-impaired, which remodel the structure and function of local neural networks by differential pruning of inhibitory synapses, thereby driving the manifestation of PTSD- and depression-like behaviors,...
Ming-Yue Zhao, Wen-Yu Tian, Xinyu Hu et al.· Brain, behavior, and immunit...· 0 citations
It is demonstrated that Ddit4 overexpression specifically in neurons is sufficient to reduce spine density in the PFC, impair temporal order memory, and induce transcriptional changes associated with stress and depression.
Alexander M. Kuhn, Kelly E. Bosis, Madeline M. Mairose et al.· eNeuro· 0 citations
Findings support alcohol-induced OL dysregulation and circuit disruption as drivers in AUD pathology and identify novel therapeutic targets aimed at ameliorating disruptions to WM integrity, diagnosing AUD, and improving outcomes for individuals impacted by AUD.
Hazen Westover, Esther Melamed, Jennifer T. Wolstenholme et al.· Physiology and Behavior· 0 citations
The results suggest that myelin plasticity in adulthood may contribute to attention and complex task performance and elucidate the role of oligodendrogenesis in post-mTBI cognitive recovery.
L. Gazdzinski, J. Mak, Miranda Mellerup et al.· Frontiers in Behavioral Neur...· 0 citations
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