Integrative network pharmacology and molecular dynamics analysis of a curcumin–indole-3-propionic acid conjugate for diabetes-associated cognitive decline
This study establishes the first network pharmacology framework for DACD and demonstrates that CUR-IPA acts as a stable, multi-target modulator of key neurodegenerative and metabolic pathways.
Asiatic acid (AA), a pentacyclic triterpenoid derived from Centella asiatica, has shown neuroprotective and anti-inflammatory activities, but the molecular network underlying its potential effects in ischemic stroke remains incompletely understood. Here, network pharmacology, protein–protein interaction (PPI) analysis,...
Findings position SRR as a hypothesis‐generating source of multi‐target candidate molecules and provide a prioritized framework for experimental validation in AD.
Archna Singh, Avijit Mazumder, A. Kanda· ChemistrySelect· 0 citations
Findings highlight APOE, BACE1, and CSF1R as key therapeutic targets as key therapeutic targets and identify compound 2a as a promising multi-target lead candidate for additional experimental validation in AD.
Md. Mainuddin Hossain, Towfika Rahman Singdha, Saiful Islam Sakib et al.· Bioinformatics and Biology I...· 0 citations
BACKGROUND
Rosacea is a chronic inflammatory skin disorder with limited therapeutic options. Puhuaiyin (PHY), a traditional Chinese medicinal formula, shows clinical efficacy, but its multi-component mechanisms remain unclear.
METHODS
Chemical constituents of PHY were identified by UPLC-Q-TOF-MS. Network pharmacology...
Dan Sun, Na-Na Yang, Yi-Ding Zhao et al.· Current Computer - Aided Dru...· 0 citations
Results from approaches examining systems and structure both indicate that ursodeoxycholic acid and tauroursodeoxycholic acid show profiles of action that work together, but they should not be interpreted as direct evidence of therapeutic efficacy in Alzheimer’s disease.
Bo Zhou, Yu Zhong, Xin Meng et al.· Pharmaceuticals· 0 citations
The findings of this study suggest that Hit1 could be a promising multi-target molecule capable of modulating cholinergic transmission, neuronal survival pathways, and oxidative stress in AD.
D. O. Onwu, R. Oria, Y. A. Adekunle et al.· Naunyn-Schmiedeberg's Archiv...· 0 citations
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