The findings demonstrate the significant potential of immunotherapy in treating CRPC, but treatment regimens require further optimization and validation of long-term survival benefits through Phase III clinical trials.
This review aims to discuss current and emerging treatment approaches based on modulation of the immune response, with particular emphasis on immune checkpoint inhibitors, targeted therapies, and mRNA vaccines.
Artur Marcysiak, Patrycja Mularczyk, Nina Polek et al.· 1 citation
The research on BsAbs in lung cancer therapy is characterized, with a focus on their mechanisms of action, clinical development, current challenges, and future directions, to represent a promising therapeutic strategy for lung cancer.
Yun-Fei Dai, Jing Fei· Translational Lung Cancer Re...· 0 citations
Key approaches targeting DNA repair deficiency, immune regulation, oncogenic signaling pathways, and antigen-directed therapies are highlighted, and their clinical development and application are discussed.
Hui-Fang Cheng, Yanmei Chen, Pei-Yan Liu et al.· Acta Pharmacologica Sinica· 0 citations
The evolving biological basis of therapeutic resistance is examined and how emerging treatment strategies may be integrated into biologically informed clinical development is discussed to improve patient selection, guide therapeutic sequencing, and increase the durability of treatment benefit in extensive-stage SCLC.
Jun Kim, Seounghun Kang· Pharmaceuticals· 0 citations
Immunotherapy has reshaped the treatment landscape of colorectal cancer (CRC), with the clearest and most durable benefit established in mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) disease. However, framing CRC immunotherapy simply as "MSI-H responsive versus microsatellite stable (MSS) res...
Current and emerging treatment approaches based on modulation of the immune response, with particular emphasis on immune checkpoint inhibitors, targeted therapies, and mRNA vaccines are discussed.
Artur Marcysiak, Patrycja Mularczyk, Nina Polek et al.· International Journal of Inn...· 0 citations
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