Metabolomics and Lipidomics Study Reveals Metabolic Dysregulation in Epididymal Adipose Tissue of db / db Mice

Bisphenol S exacerbates high-fat diet-induced obesity and insulin resistance in offspring: insights from a multi-tissue systemic lipidomic and proteomic atlas.

Bisphenol S (BPS) is a widely used substitute for bisphenol A in food-contact materials; but its role in perinatal programming of obesity and insulin resistance remains unclear. Here, we constructed a multi-tissue lipidomic-proteomic atlas to examine the effects of perinatal BPS exposure in high-fat diet-fed offspring...

Metabolomics identifies endocannabinoid system remodeling during obesity associated inflammation in adipose tissue

Adipose tissue metabolic dysregulation in diet-induced obesity: insights from UHPLC-HRMS-based metabolomics

Background Obesity and related metabolic complications are associated with adipose tissue (AT) dysfunction, which contributes to metabolic inflexibility. However, the underlying mechanisms remain unclear. Our previous studies demonstrated that a high-fat diet (HFD) induces weight gain, increased fat weight, as well as...

Deletion of Pleiotrophin protects against high-fat diet-induced liver metabolic disease, independently of the sexual dimorphism in dietary response

Obesity is a global health problem linked to the development of metabolic syndrome and comorbidities such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Pleiotrophin (PTN) is a cytokine known for its role in tissue regeneration and energy...

Targeted Metabolomics Reveals a Metabolic Signature Derived From the Stimulation of Cells With the Specific AT2R Agonist C21.

AIM Despite increasing evidence for the cardiometabolic protective effects of angiotensin II Type 2 receptor (AT2R) activation, the underlying molecular mechanisms remain incompletely understood. This study aimed to determine how AT2R activation modulates cellular metabolism and to identify pathways relevant to its tis...

Integrative transcriptomic and metabolomic profiling reveals pancreatic responses to acute exercise in mice

Abstract Acute exercise markedly alters blood glucose levels and the secretion of glucose-regulating hormones. However, as a central organ involved in glucose homeostasis, the molecular mechanisms underlying pancreatic responses to acute exercise remain poorly understood. Therefore, this study aimed to investigate the...