Theaflavin-3,3’ -Digallate Encapsulated βββββ -Chitosan Nanoparticles for the Prevention of Chemotherapy-Induced Toxicity: Mechanisms, Therapeutic Potential, and Future Perspectives
The integration of TFDG with β -CS-NPs represents a promising nanotherapeutic approach to improve treatment tolerance with preserving anticancer efficacy and their combined potential to act as a biological shield against chemotherapy-induced toxicity.
Nanocarrier-mediated delivery has shown improved pharmacokinetics, enhanced in vivo efficacy, and greater potential for synergistic combination therapies, and greater potential for synergistic combination therapies.
S. Garg, Atulika Sharma, Jeena Gupta· BioNanoScience· 0 citations
Polyphenols are among the most versatile secondary metabolites of plants, with significant therapeutic potential, including anti-inflammatory, cardioprotective, and antioxidant properties. However, limited bioavailability impedes their clinical application. These improvements have led to the use of synthetic stabilizer...
Arya Ojha, Sweta Acharya, Adarsh Sharma et al.· Frontiers in Food Science an...· 0 citations
These findings establish the nasal NLU formulation as a promising therapeutic platform to mitigate doxorubicin-induced cardiotoxicity and exhibit superior cardioprotective and antioxidant performance over the oral NFP.
H. Farouk, F. A. Abo El-Ela, Fahad H. Baali et al.· Journal of drug targeting (P...· 0 citations
Tumor-targeting efficiency and safety assessment showed insignificant changes in the systemic biomarker levels and hemocompatibility, and the developed pPBA nanoconstructs offer a novel framework for an effective and targeted delivery of therapeutics.
Sneha K Thonnamkuzhi, Sayali Dighe, Vivek Yadav et al.· Nanomedicine: Nanotechnology...· 0 citations
A promising approach to cancer therapy is presented by integrating polyphenol-based nanoformulations into hybrid nanoformulations, addressing key limitations of conventional polyphenol delivery and thereby enhancing their anticancer potential through multiple molecular pathways.
Saloni Bhandari, Bhuvanesh Baniya, Supriya Singh et al.· Current pharmaceutical desig...· 0 citations
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