2026· Advances in Experimental Medicine and Biology· Vol 1501, pp.
365-398
· 0 citations
Medicine
TL;DR
This chapter aims to provide a detailed and comprehensive overview of epigenetic drugs currently available in both preclinical and clinical testing, with a particular focus on agents directed against histone deacetylases, DNA methyltransferases, DNMTs, histone methyltransferases, histone demethylases, bromodomain and extra-terminal proteins, and mutant IDH1/2 enzymes.
This review presents an in-depth analysis of the most recent advances in small-molecule epigenetic modulators, focusing on their mechanisms of action, therapeutic applications, and the challenges impeding their clinical development, with the aim of informing the rational design and optimization of next-generation epige...
Peng Jin, Yi Wang, Na Zhao et al.· Biochimica et biophysica act...· 0 citations
Key epigenetic mechanisms, including global DNA hypomethylation, promoter CpG island hypermethylation, histone acetylation and methylation and their effects on genome stability, transcriptional regulation, stemness, immune modulation, metabolic reprogramming, and therapeutic resistance are discussed.
Elifcan Gezer, Hamed Charkhian, Ş. Tunçer· Journal of Neuropathology an...· 0 citations
Ep epigenetic dysregulation is highlighted as both a fundamental driver of leukemogenesis and a clinically actionable therapeutic interface that may enable more rational treatment sequencing and personalized AML management.
Devangi Ghosh, Mohd Ayoub, Surajit Karmakar et al.· Current Oncology Reports· 0 citations
The growing potential of metal-based epigenetic therapies to overcome therapeutic resistance through multimodal mechanisms that combine epigenetic reprogramming with modulation of DNA damage responses, oxidative stress, protein homeostasis, and chromatin organization is highlighted.
Julia Astapczuk, O. Szewczyk-Roszczenko, Y. Vassetzky et al.· Pharmacological Research· 0 citations
This review comprehensively summarizes the multifaceted roles of major histone modifications, including acetylation, methylation, ubiquitination, phosphorylation, and emerging metabolism-linked acylations, in governing critical DNA-templated processes such as replication, transcription, and the DNA damage response.
Ling-Li Wang, Shi-Ying Li, Xiao-Yan Hu et al.· Precision Clinical Medicine· 0 citations
This review provides a detailed overview of the epigenetic mechanisms that control ovarian cancer biology, with specific focus on their role in drug resistance and disease recurrence, and reviews the results of recent clinical trials.
K. Alsamman· Bioscience Reports· 0 citations
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