Aug 2026· Probiotics and Antimicrobial Proteins· 0 citations· 91 references
Medicine
TL;DR
This review aimed to synthesise the current evidence on PAP mechanisms, host-modulatory effects, and translational perspectives to present exciting avenues for clinical deployment of solutions in the early stages of development.
The emergence of antimicrobial resistance (AMR) has created a need for new, targeted alternatives to conventional antibiotics. Bacteriocins and other targeted antimicrobial peptides (AMPs) are emerging therapeutic approaches that have attracted attention for their potent antimicrobial properties and potential for more...
Vishakha Tyagi, Ajay Kumar, N. Thapliyal et al.· Applied microbiology· 0 citations
Medical biofilms are a significant problem in chronic diseases like diabetic ulcers that do not heal, infections of medical devices and CF. The extracellular polymeric matrix is a barrier to antibiotic penetration. In search of an alternative, approaches based on antimicrobial peptides (AMPs) and enzymes have been deve...
S. Shukla, B. D. Iyer· Critical reviews in microbio...· 0 citations
Antimicrobial peptides (AMPs) have been extensively investigated as alternatives to conventional antibiotics to combat multidrug-resistant bacteria. This narrow antibiotic-replacement framework underestimates the biological and translational potential of AMPs. The present review reframes them as disease-context-depende...
Min-Ho Lee· Journal of Microbiology and...· 0 citations
Antimicrobial resistance (AMR) has emerged as one of the most critical global public health challenges of the 21st century, significantly compromising the effectiveness of conventional antibiotics and increasing morbidity, mortality, and healthcare costs worldwide. In this context, plant-derived therapeutics have gaine...
Deeksha Rathor, Pushpendra Kumar, Km. Neha et al.· GLOBAL JOURNAL OF PHARMACEUT...· 0 citations
Antibiotic resistance has emerged as a critical threat to global health, food security, and economic stability due to the overuse of antibiotics in human medicine and livestock production. This review examines the mechanisms of antibiotic action and resistance, clinical and environmental consequences of resistance, and...
Haruna Abdullahi, Haliru Ahmad Kabiru, Habila Mamman Paul et al.· FUDMA Journal of Sciences· 0 citations
The growing threat of antimicrobial resistance has increased the need for anti-infective approaches beyond conventional single-target antibiotics. Defensins, a conserved family of cysteine-rich antimicrobial peptides, are promising candidates owing to their structural stability, membrane activity, target-specific mecha...
E. Abdallah, S. Al-Mijalli, N. al Hakawati et al.· Frontiers in Cellular and In...· 0 citations
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