The expression profiles of AKT-associated lncRNAs, namely LINC-ROR, MALAT1, and UCA1, in peripheral blood samples from patients with BD support the involvement of AKT-associated lncRNAs in BD pathophysiology and suggest that UCA1 may represent a candidate biomarker requiring further validation in larger independent cohorts.
BACKGROUND
Schizophrenia (SCZ) is a chronic mental disorder with unknown etiology and complex pathophysiology. Circular RNAs (circRNAs) have emerged as important regulators in neuropsychiatric disorders. This study investigated the clinical relevance, functional role, and potential mechanism of hsa_circ_0005567 in SCZ....
Jia-Le Li, Qing-Qing Zhong, Jian-Xiong Long et al.· Neuropharmacology· 0 citations
Objective To systematically characterize the epitranscriptomic landscape of N6-methyladenosine (m6A) methylation in major depressive disorder (MDD) and elucidate its functional consequences on mRNA and lncRNA regulation. Methods We performed comprehensive m6A methylome profiling using microarray analysis of peripheral...
Liang Liu, Zhao-Nan Yang, K. Tan et al.· Frontiers in Genetics· 0 citations
This computational study identifies several candidate lncRNAs associated with clinical outcomes in breast cancer, which should be interpreted as preliminary candidates, which require future validation and functional studies to determine their biological roles and evaluate their potential as prognostic biomarkers.
M. Acencio, Xin-Hui Wang, Flavia R. Rotea Mangone et al.· International Journal of Mol...· 0 citations
Background Insomnia is a prevalent sleep disorder that strongly affects one’s quality of life and physical well-being. Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestines, and a majority of IBD patients suffer from comorbid insomnia. However, the shared molecular features linking inso...
Han Guo, Xu-Dong Xu, Huan-Ying Shi et al.· Frontiers in Immunology· 0 citations
It is suggested that UPK1A-AS1 is a hypoxia‐inducible oncogenic lncRNA that plays dual roles in cancer, with cancer type‐dependent associations with progression and immune modulation across malignancies and mechanistically mediating hypoxia‐associated drug resistance in HCC.
Ze-Kai Li, Min Luo, Shu-Sen Fang et al.· Analytical Cellular Patholog...· 0 citations
This purely computational study identifies candidate dysregulated lncRNAs and predicted lncRNA–miRNA interactions in APS neutrophils, providing a hypothesis-generating framework for future experimental validation.
Yash Bisht, S. Joshi, Kajal Yadav et al.· Discover Informatics· 0 citations
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