TL;DR
Results reveal that IGF2BP2 stabilizes NRF2 mRNA via m6A modification to suppress ferroptosis, thereby promoting NPC cell survival and promoting NPC cell survival.
Ferroptosis is a non‐apoptotic form of programmed cell death driven by iron‐dependent lipid peroxidation. Induction of ferroptosis has been shown to overcome chemoresistance in cancer cells. Given the importance of the nuclear factor erythroid 2‐related factor 2 (NRF2) pathway in the regulation of cellular oxidative st...
A novel NRF2 regulatory pathway is revealed and ALDH3A2 is suggested as a promising druggable target for KEAP1-mutant tumours by performing an aldehyde dehydrogenase 3 family shRNA screen.
Long noncoding RNA SSTR5 antisense RNA 1 (lncRNA SSTR5-AS1) is increased in a variety of tumors, but its molecular mechanism in ovarian cancer (OC) remains unreported. lncRNA SSTR5-AS1 and signal transducer and activator of transcription 3 (STAT3) expressions in SKOV3 and A2780 cells were interfered (n=3), and the cel...
Nasopharyngeal carcinoma (NPC) is a malignant tumor arising from the nasopharyngeal epithelial mucosa, with its development closely associated with metabolic reprogramming. Lactylation, an epigenetic modification induced by lactate, plays a regulatory role in gene transcription.The precise function and mechanisms of H3...
It is found that KAT2B transcriptionally activates GSTZ1 in a H3K9ac-dependent manner, which in turn inhibits GPX4 expression, thereby suppressing OSCC proliferation and stemness while enhancing ferroptosis sensitivity.
It is demonstrated that PSMD11 was markedly upregulated in HCC tissues and correlated with poor patient prognosis, and a PSMD11–PSMD14–SREBP1/2-PPAR-γ–CPT1A regulatory axis that orchestrates metabolic reprogramming in HCC is uncovered.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
