TL;DR
SNC is established as a safe and effective nanocarrier system, capable of improving sorafenib bioavailability and reducing toxicity for enhanced HCC management.
Conventional paclitaxel (PTX) chemotherapy for hepatocellular carcinoma (HCC) is severely restricted by insufficient tumor-targeting specificity, unsatisfactory therapeutic efficacy, and marked systemic toxicity. To address these drawbacks, a redox-responsive and liver-targeted nanoplatform was designed for efficient P...
Hepatocellular carcinoma (HCC) is one of the most aggressive cancers with limited therapeutic efficacy and high drug resistance. This study developed a biocompatible dual-drug delivery system based on layer-by-layer liquid crystalline nanoparticles (LbL-LCNPs) co-loaded with resveratrol (RES) and hydroxychloroquine (...
ChNPs can deliver anticancer drugs to thyroid carcinoma cells with greater selectivity by utilizing both active targeting through ligand-mediated interactions and passive targeting through the increased permeability and retention effect.
Background/objective: Osimertinib, an EGFR-targeted agent approved for metastatic NSCLC, shows promise for triple-negative breast cancer due to EGFR overexpression in aggressive tumors. However, oral administration limits tumor delivery and causes systemic side effects. This study aimed to develop chitosan-coated PLGA...
Improved Cabozantinib delivery via Cabozantinib-loaded poly(lactic-co-glycolic acid) nanoparticles, prepared by solvent evaporation represents improved Cabozantinib delivery via Cabozantinib-loaded poly(lactic-co-glycolic acid) nanoparticles that overcomes pharmacokinetic pitfalls of CBZT.
Cancer remains a leading cause of death worldwide, with conventional chemotherapy often limited by poor bioavailability, rapid clearance, and systemic toxicity. This study evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) performance of three novel drug delivery systems — liposomes, polymeric nanoparticles, a...
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