Gut microbiota-targeted interventions are effective for alleviating depressive symptoms in adults with MDD-a finding supported by low-to-moderate certainty of evidence, but this finding should be interpreted with caution due to the limited certainty of evidence.
Probiotic supplementation may provide a modest adjunctive benefit for depressive symptoms in adults with MDD, however, the limited number of independent cohorts, clinical heterogeneity, risk-of-bias concerns, and imprecision resulted in low-certainty evidence according to GRADE.
M. Y. Alsmadi· Natural Resources for Human...· 0 citations
BACKGROUND
Chronic low-grade inflammation has been widely acknowledged as an important pathophysiological mechanism underlying depression. Probiotics may alleviate depressive symptoms by modifying the microbiota-gut-brain axis and regulating inflammatory responses. The purpose of this systematic review and meta-analysi...
Faeze Lachinani, Alireza Milajerdi· Progress in Neuro-psychophar...· 0 citations
Background/Objectives: Stress is increasingly recognized as an important modulator of gut microbiome composition and function through the bidirectional microbiota–gut–brain axis. Dietary, psychobiotic, and other lifestyle-oriented interventions have therefore attracted growing interest as potential strategies for simul...
S. Asimakopoulou, Panagiotis Pipelias, Eva Kassi et al.· Nutrients· 0 citations
A systematic review of clinical studies evaluating gut microbiota composition in adult patients with Major Depressive Disorder found MDD-associated dysbiosis drives neuroinflammation via the gut–brain axis, as conceptualized in the NIMETOX framework.
Kalina Światlak, W. Żelazna, Justyna Trzaskalik· Journal of Education, Health...· 0 citations
Overall, MGBA-related nutritional and psychobiotic interventions may contribute to mood-symptom management by modulating microbial, metabolic, immune, neuroendocrine, and neurotrophic pathways, but robust symptom-biomarker bridging evidence remains limited.
Qiu-Hua Dai, Chaonv Fang, Ya-Jun Du et al.· Frontiers in Nutrition· 0 citations
Background: Emerging evidence suggests that the gut–brain axis plays a significant role in the pathophysiology of depression, highlighting probiotics as a potential therapeutic intervention. However, findings from randomized controlled trials (RCTs) remain inconsistent.
Objective: To evaluate the efficacy of probiotic...
Prashant Mangla, Aarushi Mangla· Greenfort International Jour...· 0 citations
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