Jul 2026· Journal of Multidisciplinary Applied Natural Science· Vol 6, pp. 1560-1572· 0 citations· 42 references
TL;DR
Results indicate the prenylated xanthones from C. biflorum as antioxidant agents, and suggest their cytotoxicity toward 4T1 breast cancer cells is low.
Abstract
The Calophyllum genus, part of the Calophyllaceae family, produces xanthones as dominant secondary metabolites. Calophyllum biflorum M.R. Hend. & Wyatt-Sm. is an endemic plant of Kalimantan; however, the potential of its xanthone content and biological activity has never been explored. In this study, three known prenylated xanthones: gartanin (1), ananixanthone (2), and α-mangostin (3), were isolated from C. biflorum leaves. Their chemical structures were determined by HRMS and 1D/2D NMR. The antioxidant activities of xanthones 1–3 (via DPPH radical) and their cytotoxicity toward 4T1 breast cancer cells were assessed. Xanthones 1–2 showed strong DPPH activity (IC50: 4.40 and 34.34 µM, respectively). Gartanin (1) also exhibited moderate activity against 4T1 cells (IC50 =16.70 µM). These results indicate the prenylated xanthones from C. biflorum as antioxidant agents.
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