Aug 2026· Journal of physiology and biochemistry· Vol 82· 0 citations· 133 references
Medicine
TL;DR
Recent advances in the mechanisms by which AMPK regulates necroptosis are summarized and unresolved questions are highlighted, including the cell-type-specific roles of AMPK subunits, the contribution of additional autophagy regulators, the balance between mTORC1-dependent protective signaling and RIPK3 stability, and the in vivo relevance of the AMPK-SIRT1-PGAM5 axis are highlighted.
Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...
Yun-Tian Shen, Haiyan Jiang, Jie Wang et al.· Biochemical Pharmacology· 0 citations
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has emerged as a critical mechanism in tumor suppression and a promising target for cancer therapy. As a reversible and dynamic post-translational modification, phosphorylation orchestrated by protein kinases serves as a pivotal r...
Beining Yang, Junxiang Pi, Xueli Bian· European Journal of Cell Bio...· 0 citations
How fluctuations in central metabolites are transduced into cell-death decisions remains poorly understood. Here we show that lactate directly promotes necroptosis through lactylation of receptor-interacting protein kinase 3 (RIPK3) at lysine 63 (K63). Large-scale screening identified LDH inhibition as a suppressor of...
Nai-Jin Zhang, Xin-Yue Huang, Sai-En Lu et al.· Cell Metabolism· 0 citations
Highlights What are the main findings? AMPK activity is regulated not only by cellular energy status but also by upstream kinases, post-translational modifications, heterotrimer composition, and subcellular compartmentalization. Recent advances in indirect, direct, isoform-selective, and compartment-selective AMPK acti...
Hannah Ceballos, E. Zhang, Wendong Huang· Cells· 0 citations
Recent advances in understanding the multifaceted roles of AMPK during flavivirus infection are summarized, with an emphasis on its regulation of metabolic reprogramming, organelle remodeling, and antiviral immunity.
Current understanding of PINK1-Parkin-dependent and independent mitophagy pathways are summarized, highlighting mechanistic distinctions and coordinated regulation, as well as the expanding therapeutic potential of targeting mitophagy in disease.
S. Martens, Ian G. Ganley· Nature reviews. Molecular ce...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
