Systems pharmacology and targeted transcriptional profiling suggest the putative neuroprotective role of Leuconostoc mesenteroides in an in vitro Alzheimer’s disease model

Bioactivated Glucoraphanin Exerts a Potential Protective Effect in an In Vitro Model of Parkinson’s Disease: A Transcriptomic Study

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor symptoms. Oxidative stress is involved in disease pathogenesis, with the consequent damage to DNA. Nowadays, phytocompounds attract much interest for their capacity to modulate some of the pathogenic mechanism...

Integrating network pharmacology and experimental validation to uncover the mechanisms of Ganoderma lucidum in ameliorating neuroinflammation in Alzheimer's disease.

Protocatechuic acid alleviates the progression of Alzheimer's disease by regulating p53/GADD45/MAPK signaling pathway.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder worldwide lacking effective treatments. Protocatechuic acid (PCA), a natural polyphenol found in various foods and medicinal herbs, exhibits diverse bioactivities; but its role in AD remains unclear. This study investigated the neuroprotective effects a...

Integrating Network Pharmacology and Molecular Docking to Uncover Neuroprotective Phytochemicals From Symplocos racemosa Roxb. in Mitigating Alzheimer's Disease

Findings position SRR as a hypothesis‐generating source of multi‐target candidate molecules and provide a prioritized framework for experimental validation in AD.

Integrated proteomics and network pharmacology reveal autophagy-lysosomal regulation underlying sulforaphane-mediated neuroprotection in Alzheimer's disease.

SFN pretreatment protected against Aβ-induced neuronal injury in this in vitro model and was associated with modulation of autophagy-lysosomal and apoptosis-related pathways, a systems-level framework for understanding the multitarget neuroprotective actions of SFN.

Multi-Target Neuroprotective Effects of Baicalein in Parkinson’s Disease

Baicalein may exhibit multi-target neuroprotective activity in PD by modulating integrity and oxidative stress–associated signaling pathways, and convergence of computational and in vitro findings supports its role in restoring neuronal redox balance and enhancing cellular resilience.