Aug 2026· European Archives of Psychiatry and Clinical Neuroscience· Vol 276, pp. 3329 - 3341· 0 citations· 47 references
Medicine
TL;DR
P-tau217 has poorer diagnostic performance in the stages of cognitive unimpaired or less cognitively impaired, especially in the Aβ positivity diagnosis of SCD and CU, which is consistent with the guidelines.
Increased serum p-tau217 and decreased ApoE levels were significantly associated with greater AD severity, suggesting that both biomarkers may serve as complementary noninvasive indicators of disease severity in Alzheimer’s disease.
Ahmed Kadom Kalaf, Khawla A. Shemran, Waleed Azeez AlAmeedy· International Journal of Nut...· 0 citations
The plasma p-tau217/Aβ42 ratio functions as an effective first-line screening tool that resolves ambiguous cases, significantly decreases gray-zone classifications, and increases diagnostic confidence, but does not significantly enhance absolute diagnostic discrimination (AUC) relative to p-tau217 alone.
Adil Khan, Awais Ahmad, Usman Khan et al.· Journal of Saidu Medical Col...· 0 citations
Introduction: Alzheimer’s disease (AD) is the most common cause of dementia, accounting for 60–80% of cases, and its prevalence is increasing as the population ages. It is estimated that approximately 50 million people worldwide currently live with dementia, and this number could triple by 2050. AD is a chronic, progre...
Mateusz Cieciora, M. Kawiorska, Julia Surowiec et al.· International Journal of Inn...· 0 citations
Plasma p-tau217 showed high diagnostic performance for identifying amyloid and tau pathology and generally outperformed other phosphorylated tau isoforms, but it should not be interpreted as a stand-alone test.
Oliwia Lenkiewicz, Julia Lenkiewicz, Z. Chmielewska et al.· International Journal of Inn...· 0 citations
Among patients with isolated AD or isolated CSVD, plasma p-Tau217 is the optimal specific biomarker for the diagnosis of AD and differentiation between AD and cerebral small vessel disease.
Xian-Dong Wang, Jun-Qiu Wu, Xuan Zhang et al.· Frontiers in Neurology· 0 citations
OBJECTIVE
Recent studies suggest that combining plasma phosphorylated tau (p-tau) with β-amyloid (Aβ) may improve diagnosis accuracy for Alzheimer's disease (AD). However, the cross-sectional and longitudinal concordance of these markers with Aβ positron emission tomography (PET) positivity remains incompletely underst...
Mingxing Jiang, Guo-Yu Lan, Jiayi Zhu et al.· Annals of Neurology· 0 citations
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