Neural stem cell-derived small extracellular vesicles ameliorate disease progression in the SOD1 G93A murine model of amyotrophic lateral sclerosis.

Y.S. Wan Chao Gao Jieyu Li Mingyue Luan Yuxuan Lu Jiaxin Wang Bi-Yu Yang Jie Zheng Yun Yuan Jun Wei Zhao-Xia Wang Jianwen Deng

Aug 2026 · Journal of Neuropathology and Experimental Neurology · 0 citations

Medicine

TL;DR

It is found that repeated administration of neural stem cell-derived extracellular vesicles (NSC-derived EVs) improved motor performance and provided protection to lumbar motor neurons, the neuromuscular junctions, and muscle morphology in the SOD1 G93A transgenic mouse model of ALS.

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